ID A0A1H6J244_9FLAO Unreviewed; 225 AA.
AC A0A1H6J244;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN ORFNames=EGH73_06075 {ECO:0000313|EMBL:ROI13888.1}, SAMN05421793_11077
GN {ECO:0000313|EMBL:SEH54242.1};
OS Epilithonimonas hominis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Chryseobacterium group; Epilithonimonas.
OX NCBI_TaxID=420404 {ECO:0000313|EMBL:SEH54242.1, ECO:0000313|Proteomes:UP000198555};
RN [1] {ECO:0000313|EMBL:SEH54242.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19326 {ECO:0000313|EMBL:SEH54242.1};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000198555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19326 {ECO:0000313|Proteomes:UP000198555};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ROI13888.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22165 {ECO:0000313|EMBL:ROI13888.1};
RA Nicholson A.C., Gulvik C.A., Whitney A.M., Humrighouse B.W., Bell M.,
RA Holmes B., Steigerwalt A., Villarma A., Sheth M., Batra D., Pryor J.,
RA Bernardet J.-F., Hugo C., Kampfer P., Newman J., Mcquiston J.R.;
RT "Proposal to divide the Flavobacteriaceae and reorganize its genera based
RT on Amino Acid Identity values calculated from whole genome sequences.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Proteomes:UP000267623}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22165 {ECO:0000313|Proteomes:UP000267623};
RA Nicholson A.C., Gulvik C.A., Whitney A.M., Humrighouse B.W., Bell M.,
RA Holmes B., Steigerwalt A., Villarma A., Sheth M., Batra D., Pryor J.,
RA Bernardet J.-F., Hugo C., Kampfer P., Newman J., Mcquiston J.;
RT "Proposal to divide the Flavobacteriaceae and reorganize its genera based
RT on Amino Acid Identity values calculated from whole genome sequences.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
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DR EMBL; RJTU01000040; ROI13888.1; -; Genomic_DNA.
DR EMBL; FNWX01000010; SEH54242.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H6J244; -.
DR STRING; 420404.SAMN05421793_11077; -.
DR Proteomes; UP000198555; Unassembled WGS sequence.
DR Proteomes; UP000267623; Unassembled WGS sequence.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd03141; GATase1_Hsp31_like; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR PANTHER; PTHR48094:SF11; GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 4: Predicted;
KW Glutamine amidotransferase {ECO:0000313|EMBL:ROI13888.1};
KW Hydrolase {ECO:0000313|EMBL:SEH54242.1};
KW Protease {ECO:0000313|EMBL:SEH54242.1};
KW Stress response {ECO:0000256|ARBA:ARBA00023016};
KW Transferase {ECO:0000313|EMBL:ROI13888.1}.
FT DOMAIN 23..223
FT /note="DJ-1/PfpI"
FT /evidence="ECO:0000259|Pfam:PF01965"
FT REGION 46..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 225 AA; 24830 MW; E855F1AEE3890E58 CRC64;
MNKKILFVVT SHEDLGNTGL KTGFWTEELA APYYVLADQG AEITIATPKG GQPPIDPKSE
DPSAQTDATR RMDTDKVLLE KLRNTKVLSE INSADYDAVF YPGGHGPLWD LAEDKISQQL
ITDFYKADKP VAFVCHAPGV LRHVQIDGEY LVNGKKVTGF TNTEEEAVQL TDVVPFLVED
MLKQNGGEYS KVEDWQPYAV VDGKLITGQN PASSEKVAEE LLKML
//
