ID A0A1H6KAQ3_9FLAO Unreviewed; 452 AA.
AC A0A1H6KAQ3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Hemolysin, contains CBS domains {ECO:0000313|EMBL:SEH68543.1};
GN ORFNames=SAMN05421793_12015 {ECO:0000313|EMBL:SEH68543.1};
OS Epilithonimonas hominis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Chryseobacterium group; Epilithonimonas.
OX NCBI_TaxID=420404 {ECO:0000313|EMBL:SEH68543.1, ECO:0000313|Proteomes:UP000198555};
RN [1] {ECO:0000313|Proteomes:UP000198555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19326 {ECO:0000313|Proteomes:UP000198555};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FNWX01000020; SEH68543.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H6KAQ3; -.
DR STRING; 420404.SAMN05421793_12015; -.
DR Proteomes; UP000198555; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR PANTHER; PTHR43099; UPF0053 PROTEIN YRKA; 1.
DR PANTHER; PTHR43099:SF2; UPF0053 PROTEIN YRKA; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01595; CNNM; 1.
DR Pfam; PF03471; CorC_HlyC; 1.
DR SMART; SM01091; CorC_HlyC; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS51371; CBS; 2.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 6..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 58..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..205
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 224..284
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 292..349
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT COILED 332..359
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 452 AA; 51351 MW; 9E747569B08BB054 CRC64;
MDPDSLVKLL IALFLVLLNG FFVAAEFSIV KVRYSQIQIK AAEGNTMAKQ AESIIKNLDA
YLSATQLGIT LASLALGWVG ESALHHIIEG IFHSLDIELA QTTVTTISVV CSFLLITIMH
IVFGELVPKS IAIRKSEATT LFIAYPLHLF YNIFRPFIWL MNSLSNGFLK IIKIHPVSEH
DIHSTEELQL LVKQSADSGE IEEENYEIIK NAFDFTDHNA KQIMIPRQNI SSIDIEDDKE
EIISKIMDSG YSRIPVYEGS IDNIIGIFYT KEIIREYIKS KGELTHEDLR GLMREAFFVV
GSKKISDLLK VFQFKKQHMA IVIDEFGGTE GIITLEDILE ELVGEIQDEE DEEEKIVDKV
GENTYWVKAT QPLEEINECI PKKIPPSEEG EYNTLAGFIL NELQDIPEEN QEFDYGPYHF
KILKMQNKSV ELVELFYNKS LVDDITDEIT EG
//
