ID   A0A1H6KDF3_9BACT        Unreviewed;       667 AA.
AC   A0A1H6KDF3;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Heparinase ii/iii n-terminus {ECO:0000313|EMBL:SEH69485.1};
GN   ORFNames=PYTT_0036 {ECO:0000313|EMBL:SEH69485.1};
OS   Akkermansia glycaniphila.
OC   Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC   Akkermansiaceae; Akkermansia.
OX   NCBI_TaxID=1679444 {ECO:0000313|EMBL:SEH69485.1, ECO:0000313|Proteomes:UP000176204};
RN   [1] {ECO:0000313|Proteomes:UP000176204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Koehorst J.;
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000256|ARBA:ARBA00004418}.
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DR   EMBL; LT629973; SEH69485.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H6KDF3; -.
DR   STRING; 1679444.PYTT_0036; -.
DR   KEGG; agl:PYTT_0036; -.
DR   OrthoDB; 7335480at2; -.
DR   Proteomes; UP000176204; Chromosome i.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.70; -; 1.
DR   Gene3D; 1.50.10.100; Chondroitin AC/alginate lyase; 1.
DR   InterPro; IPR008929; Chondroitin_lyas.
DR   InterPro; IPR012480; Hepar_II_III.
DR   InterPro; IPR031680; Hepar_II_III_N.
DR   PANTHER; PTHR39210; HEPARIN-SULFATE LYASE; 1.
DR   PANTHER; PTHR39210:SF1; HEPARIN-SULFATE LYASE; 1.
DR   Pfam; PF07940; Hepar_II_III; 1.
DR   Pfam; PF16889; Hepar_II_III_N; 1.
DR   SUPFAM; SSF48230; Chondroitin AC/alginate lyase; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Periplasm {ECO:0000256|ARBA:ARBA00022764};
KW   Reference proteome {ECO:0000313|Proteomes:UP000176204};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          31..381
FT                   /note="Heparin-sulfate lyase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16889"
SQ   SEQUENCE   667 AA;  77931 MW;  73A537AB74518813 CRC64;
     MMKTMIFFAC LLAVWLGLAA GEDVRVIRRE AFALLDLDRP GLEDVKALHE QGKDHEAAKA
     LLAYYRNRAG VRIPGKVSLS EEEEHWANDA VKHIFYVRGV RQDSLFYGEE IDWTYWPVRD
     NELRWQLHRH KWFTPLGKAY RMSGEEMYAE AWVHQYRDWI RKNPLLSDEE RKKRRQGSQG
     EIDEVENMRF AWRSLEVSHR LQDQIMQFRL FLDSPSFTPE FLTEFLVNYH RHAAHIMGHY
     SQRGNHLLFE SQRMIAAGSF FHEFRDAAAW RKSGINILNR EITAQVYEDG GQMELDPGYH
     LASINLFRKA LELAEKNGFR DEFPLGYSDV IEKMIMFHAN ISFPDYSNPC FSDAKLHGRR
     VMLRNYRVWS DLFPKNEAIR YFATEGREGA LPGYLSKGFP DSGFFVFRNS WGMDATQMVV
     KAGPKAFWHN QPDNGTFELW FKGRRLFPDS GSYMYGGEGE IQEQRDWHRQ TCVHNTATLD
     DRNLENTESV TRLWQPDGEE QVLVTENRSY RDLKHRRSVF FVDGRYFVIV DELDGKAVGT
     VNLHYQMPEG EIVHSSREMA FSTQFEDGSR MMLQCFGPAG MSVRQEDGWY SEKSRNRRKR
     MRISFDARKD GEEAVRYVTV ICPVDAKGDV PRFHAEFGNA KFDEYGLKVN VSVDGKSRVL
     AYELDRP
//