ID A0A1H6L8M9_9BACT Unreviewed; 407 AA.
AC A0A1H6L8M9;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=tyrosine--tRNA ligase {ECO:0000256|ARBA:ARBA00013160};
DE EC=6.1.1.1 {ECO:0000256|ARBA:ARBA00013160};
GN ORFNames=PYTT_0907 {ECO:0000313|EMBL:SEH80848.1};
OS Akkermansia glycaniphila.
OC Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC Akkermansiaceae; Akkermansia.
OX NCBI_TaxID=1679444 {ECO:0000313|EMBL:SEH80848.1, ECO:0000313|Proteomes:UP000176204};
RN [1] {ECO:0000313|Proteomes:UP000176204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Koehorst J.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-
CC tyrosyl-tRNA(Tyr); Xref=Rhea:RHEA:10220, Rhea:RHEA-COMP:9706,
CC Rhea:RHEA-COMP:9707, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:58315, ChEBI:CHEBI:78442,
CC ChEBI:CHEBI:78536, ChEBI:CHEBI:456215; EC=6.1.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000069};
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|RuleBase:RU363036}.
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DR EMBL; LT629973; SEH80848.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H6L8M9; -.
DR STRING; 1679444.PYTT_0907; -.
DR KEGG; agl:PYTT_0907; -.
DR Proteomes; UP000176204; Chromosome i.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004831; F:tyrosine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006437; P:tyrosyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00805; TyrRS_core; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 1.10.240.10; Tyrosyl-Transfer RNA Synthetase; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002305; aa-tRNA-synth_Ic.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR002307; Tyr-tRNA-ligase.
DR InterPro; IPR024088; Tyr-tRNA-ligase_bac-type.
DR NCBIfam; TIGR00234; tyrS; 1.
DR PANTHER; PTHR11766:SF1; TYROSINE--TRNA LIGASE; 1.
DR PANTHER; PTHR11766; TYROSYL-TRNA SYNTHETASE; 1.
DR Pfam; PF00579; tRNA-synt_1b; 1.
DR PRINTS; PR01040; TRNASYNTHTYR.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363036};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363036};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363036};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363036};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363036};
KW Reference proteome {ECO:0000313|Proteomes:UP000176204}.
SQ SEQUENCE 407 AA; 45877 MW; FCF72B194718DD15 CRC64;
MCGVGWAYWR PHVMTPEEQL DLLMRGTAKV LNPSELLERL KSGRPLRVKL GVDPTAPDIH
LGHTVAIEKL RQFQMLGHQA VLIIGDFTAT IGDPTGRSVT RPPLTRDEVL ANAETYTEQA
FKILDKEKTE IVYNGDWFRK MVYEEVLKLN ARVTMQQILA REDFRSRIDS GKEVRLHEMQ
YPVMQGWDSV MVKSDVELGG TDQLFNILVG RDLQREEGMQ PQIAMVLPLL EGLDGTRKMS
KSYGNYVGVS EPAETMFGKL MSASDELMDR YYTVLLGESR DESLHPMEAK KLLAWKITAR
YHSADDADAA RADWETRFSK RDLAAADLPE VSIAALPDEL NYMSLVAHLF ETVFDLKKSN
GVLRKEHFTP GAIQLDGEKI VDPFALPVLH PGAVLRLSKK HAVRFAA
//
