ID A0A1H6SCJ9_9FLAO Unreviewed; 586 AA.
AC A0A1H6SCJ9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Phenylalanine-4-hydroxylase {ECO:0000313|EMBL:SEI61740.1};
GN ORFNames=SAMN05660918_1163 {ECO:0000313|EMBL:SEI61740.1};
OS Flavobacterium terrigena.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=402734 {ECO:0000313|EMBL:SEI61740.1, ECO:0000313|Proteomes:UP000199702};
RN [1] {ECO:0000313|EMBL:SEI61740.1, ECO:0000313|Proteomes:UP000199702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17934 {ECO:0000313|EMBL:SEI61740.1,
RC ECO:0000313|Proteomes:UP000199702};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|PIRSR:PIRSR601273-2};
CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
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DR EMBL; FNYA01000002; SEI61740.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H6SCJ9; -.
DR STRING; 402734.SAMN05660918_1163; -.
DR OrthoDB; 9780502at2; -.
DR Proteomes; UP000199702; Unassembled WGS sequence.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016714; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR CDD; cd00361; arom_aa_hydroxylase; 1.
DR Gene3D; 1.20.58.690; -; 1.
DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR InterPro; IPR001273; ArAA_hydroxylase.
DR InterPro; IPR036951; ArAA_hydroxylase_sf.
DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR PANTHER; PTHR11473:SF24; PHENYLALANINE-4-HYDROXYLASE; 1.
DR Pfam; PF00351; Biopterin_H; 2.
DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601273-2};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR601273-2};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 1..342
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT BINDING 131
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 136
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 221
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
SQ SEQUENCE 586 AA; 65239 MW; CEC99354F66C2E37 CRC64;
MESNFESNPL IDRLPKHLKQ FIIPQDYNDY TPINQAVWRY VMRKNVDYLS KVAHNSYLEG
LDKTGLEIDN IPNMYGMNRI LKEIGWAAVA VDGFIPPSAF MEFQAYNVLV IACDIRQLEH
IEYTPAPDII HEGAGHAPII ANPEYAEYLR RFGEIGCKAI SSARDYELYE AVRLLSIVKE
AEGTPAEEIK AAEDQVDFLQ NNMGELSEMS KIRNLHWWTV EYGLIGTVEN PKIYGAGLLS
SIGESAWCMT DNVKKIPYDI SAADQSFDIT KPQPQLYVTP DFAQLSSVLE EFASKMALRT
GGLSGIQKLI TSKNLGTVEL STGLQISGVF TNVIENEGKP VYIQTTGKTA LSYREKELVS
HGTDAHAEGF GSPVGKLKGI NLAIEDMGPR DLRAYDIYEG EQITLEFEGN IKVSGEIVTG
TRNLQGEILL IKFKNCTVTQ GETILFAPEW GIYDMAVGKK ITSAFSGPAD VNSFDMISHV
PSSHTIKQKK SAEREELEGL YRNVRNLREG KAAEITLKEA FGAVTANHKN DWLLSVEIAE
LAKKENNTDL IDKVLNHLEK VKINRPEVAH LIDGGLELIF EKATNL
//
