ID   A0A1H6ST74_9EURY        Unreviewed;       290 AA.
AC   A0A1H6ST74; A0A2H4Q6A0;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Precorrin-3 methyltransferase {ECO:0000313|EMBL:SEI67967.1};
GN   ORFNames=SAMN05444271_105132 {ECO:0000313|EMBL:SEI67967.1};
OS   Halohasta litchfieldiae.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Halorubraceae; Halohasta.
OX   NCBI_TaxID=1073996 {ECO:0000313|EMBL:SEI67967.1, ECO:0000313|Proteomes:UP000198888};
RN   [1] {ECO:0000313|EMBL:SEI67967.1, ECO:0000313|Proteomes:UP000198888}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22187 {ECO:0000313|EMBL:SEI67967.1,
RC   ECO:0000313|Proteomes:UP000198888};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004953}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FNYR01000005; SEI67967.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H6ST74; -.
DR   STRING; 1073996.SAMN05444271_105132; -.
DR   OrthoDB; 192663at2157; -.
DR   UniPathway; UPA00148; -.
DR   Proteomes; UP000198888; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd11646; Precorrin_3B_C17_MT; 1.
DR   InterPro; IPR000878; 4pyrrol_Mease.
DR   InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR   InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR   InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR   InterPro; IPR006363; Cbl_synth_CobJ/CibH_dom.
DR   PANTHER; PTHR47036; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR   PANTHER; PTHR47036:SF1; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR   Pfam; PF00590; TP_methylase; 1.
DR   SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE   4: Predicted;
KW   Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:SEI67967.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198888};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SEI67967.1}.
FT   DOMAIN          20..245
FT                   /note="Tetrapyrrole methylase"
FT                   /evidence="ECO:0000259|Pfam:PF00590"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   290 AA;  31732 MW;  B096CFD75C7EE356 CRC64;
     MSSESTDSST VDQPDDLGTL SVVGIGPGLP DDMTQRAKRV IETADCVIVS DLYQAFLRDD
     GSLPPKDEVD DDGFVTRDNG HQQEIIRSTM GRQIELAKVA FERVREGDDV AHVSGGDPSV
     YGKSDLIFKM AEEEDATDVP IEIVPGITAA LGGGAMVGAP LCNDFCTISL SDKWRGWEEI
     EQKLRAAAIS DFVIVLYNCW RNYEKAVDIV REERTDDALV AIVNDAGRKD AGRNGEDHFI
     TTLGEATDHD QKVSGMGTSL IIGNHETETW SNDYRTFLVT PRGGRDVENF
//