ID   A0A1H6SVP4_9ACTN        Unreviewed;       495 AA.
AC   A0A1H6SVP4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=RfaE bifunctional protein, domain I/rfaE bifunctional protein, domain II {ECO:0000313|EMBL:SEI68025.1};
GN   ORFNames=SAMN05443287_101743 {ECO:0000313|EMBL:SEI68025.1};
OS   Micromonospora phaseoli.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=1144548 {ECO:0000313|EMBL:SEI68025.1, ECO:0000313|Proteomes:UP000198707};
RN   [1] {ECO:0000313|Proteomes:UP000198707}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.7038 {ECO:0000313|Proteomes:UP000198707};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004713}.
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DR   EMBL; FNYV01000001; SEI68025.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H6SVP4; -.
DR   STRING; 1144548.SAMN05443287_101743; -.
DR   OrthoDB; 9802794at2; -.
DR   UniPathway; UPA00958; -.
DR   Proteomes; UP000198707; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   InterPro; IPR002173; Carboh/pur_kinase_PfkB_CS.
DR   InterPro; IPR004821; Cyt_trans-like.
DR   InterPro; IPR011611; PfkB_dom.
DR   InterPro; IPR029056; Ribokinase-like.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR   PANTHER; PTHR43793:SF2; BIFUNCTIONAL PROTEIN HLDE; 1.
DR   PANTHER; PTHR43793; FAD SYNTHASE; 1.
DR   Pfam; PF01467; CTP_transf_like; 1.
DR   Pfam; PF00294; PfkB; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF53613; Ribokinase-like; 1.
DR   PROSITE; PS00584; PFKB_KINASES_2; 1.
PE   4: Predicted;
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          5..297
FT                   /note="Carbohydrate kinase PfkB"
FT                   /evidence="ECO:0000259|Pfam:PF00294"
FT   DOMAIN          337..427
FT                   /note="Cytidyltransferase-like"
FT                   /evidence="ECO:0000259|Pfam:PF01467"
FT   REGION          469..495
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   495 AA;  49976 MW;  8E37B186E77BC6FA CRC64;
     MTGPVVVLGD TLLDRDVEGA VNRLCPDSPV PVLDESAHVD RPGGAGLSAV FAAAQGAEVV
     LVTALADDAG GARLSVLLAA AGVQVYPLRL AGSTPEKIRL RAGGRVLLRH DRGGGAGEPG
     EPPEAVLRLL ERASVVLVSD YGRGVARQGA LRAALASVRA PVVWDPHPRG PAAVPGAHLV
     TPNEAEVREL MEAPAGATRL ATAAQGAQRL RQRWRAGAVS VTLGCDGALL SHAGTTPLVV
     PAPVAAEGDT CGAGDRFAVA ASLALARGAL VSEAVQEAVA EASAFVADGG VATALPATVR
     RAPQAAHNVV AGDRVGVAAA AAVVARVRAA GGTVVATGGC FDLLHAGHVA TLQAARQLGD
     CLVVCLNSDA SVTGLKGPDR PVIRQDDRSR LLAALSCVDA VMIFDEPTPA AALSWLRPDI
     WVKGGDYSAG GGDGDNLPEA AILRRWGGDT VVVPYLDGRS TTEMIAAARA GGPPDPRMLV
     TATPAVAPES TEAAR
//