ID A0A1H6TB48_9EURY Unreviewed; 266 AA.
AC A0A1H6TB48; A0A2H4Q071;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Translation initiation factor 2 subunit alpha (AeIF-2a) {ECO:0000313|EMBL:SEI75384.1};
GN ORFNames=SAMN05444271_10758 {ECO:0000313|EMBL:SEI75384.1};
OS Halohasta litchfieldiae.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Halorubraceae; Halohasta.
OX NCBI_TaxID=1073996 {ECO:0000313|EMBL:SEI75384.1, ECO:0000313|Proteomes:UP000198888};
RN [1] {ECO:0000313|EMBL:SEI75384.1, ECO:0000313|Proteomes:UP000198888}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22187 {ECO:0000313|EMBL:SEI75384.1,
RC ECO:0000313|Proteomes:UP000198888};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the eIF-2-alpha family.
CC {ECO:0000256|ARBA:ARBA00007223}.
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DR EMBL; FNYR01000007; SEI75384.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H6TB48; -.
DR STRING; 1073996.SAMN05444271_10758; -.
DR OrthoDB; 84794at2157; -.
DR Proteomes; UP000198888; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd04452; S1_IF2_alpha; 1.
DR Gene3D; 3.30.70.1130; EIF_2_alpha; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR044126; S1_IF2_alpha.
DR InterPro; IPR024055; TIF2_asu_C.
DR InterPro; IPR024054; TIF2_asu_middle_sf.
DR InterPro; IPR011488; TIF_2_asu.
DR PANTHER; PTHR10602; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1; 1.
DR PANTHER; PTHR10602:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1; 1.
DR Pfam; PF07541; EIF_2_alpha; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF110993; eIF-2-alpha, C-terminal domain; 1.
DR SUPFAM; SSF116742; eIF2alpha middle domain-like; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:SEI75384.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000198888}.
FT DOMAIN 10..81
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REGION 235..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 266 AA; 29534 MW; 8F2D0C17F55F6CEE CRC64;
MKYSGWPETG DLVVGKVDEI TDFGVFVDLD EYENKRGLAH ISEVASGWIK NVRDHVRVGQ
TVVAKVLDVN ESSQQIDLSI KDVNEHQRKE KIQEWKNEQK ADNWMLLALG EEVDDETYGA
VANGLLAEYE SLYDAFEQAA IHGGEALEDT DLSDEEIESI VETARENVSV PYVNVTGYVD
LECPAPDGVD VVKEALKAAE GNGEIPNEIE LSVSYVGSPE YRIKVRAPDY KTAERELESS
ADRAKEAIEA AGGSGHYHRE RSEEDE
//
