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Database: UniProt
Entry: A0A1H6TG75_9FIRM
LinkDB: A0A1H6TG75_9FIRM
Original site: A0A1H6TG75_9FIRM 
ID   A0A1H6TG75_9FIRM        Unreviewed;       394 AA.
AC   A0A1H6TG75;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   16-JAN-2019, entry version 5.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   ORFNames=SAMN02910453_1329 {ECO:0000313|EMBL:SEI75235.1};
OS   Lachnospiraceae bacterium A10.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae.
OX   NCBI_TaxID=1520821 {ECO:0000313|EMBL:SEI75235.1, ECO:0000313|Proteomes:UP000198998};
RN   [1] {ECO:0000313|EMBL:SEI75235.1, ECO:0000313|Proteomes:UP000198998}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A10 {ECO:0000313|EMBL:SEI75235.1,
RC   ECO:0000313|Proteomes:UP000198998};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
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DR   EMBL; FNYN01000003; SEI75235.1; -; Genomic_DNA.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000198998; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR016204; HDH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000198998};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR000098-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198998};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN        2    118       NAD_binding_3. {ECO:0000259|Pfam:
FT                                PF03447}.
FT   DOMAIN      126    304       Homoserine_dh. {ECO:0000259|Pfam:
FT                                PF00742}.
FT   NP_BIND       1      8       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   ACT_SITE    194    194       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000098-1}.
FT   BINDING      94     94       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   BINDING     179    179       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000098-2}.
SQ   SEQUENCE   394 AA;  43091 MW;  7D817ED3CCB340CA CRC64;
     MGYGTIGSGV AEILRVNREV IAKRAGEPLE LKYVLDLREF KGDPVEHLIV HDYETIVNDP
     EVDIVVETMG GVEPAYTFVK AMLEKGKHVT TSNKALVAEK GAELIRIARE HKVNFLFEAS
     VGGGIPIIRP LLSSLTGDVV EEITGIVNGT TNYMLTKMAK EGSDFDEVLK EAQANGYAEK
     DPTADVEGHD ACRKIAILTS LVCGQQVDYR DIPTEGITKI SATDIKYANA LGKVIKLLAR
     SKKVGDTYVC RVAPYLLGPS HPLHHVDGVF NAIFVHGNMF GDGMFYGSGA GKLPTASAVV
     GDMVAMAKHI DKNIYLEWEE EPLILSNPNQ QENTFFVRTG ASKEEIEAAF YHVEYVDAGI
     PDEIGFITVK MTEADFARKL ESVSDVRQTL RLAD
//
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