ID A0A1H6TQ74_9EURY Unreviewed; 908 AA.
AC A0A1H6TQ74; A0A2H4Q3C7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SAMN05444271_10855 {ECO:0000313|EMBL:SEI79367.1};
OS Halohasta litchfieldiae.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Halorubraceae; Halohasta.
OX NCBI_TaxID=1073996 {ECO:0000313|EMBL:SEI79367.1, ECO:0000313|Proteomes:UP000198888};
RN [1] {ECO:0000313|EMBL:SEI79367.1, ECO:0000313|Proteomes:UP000198888}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22187 {ECO:0000313|EMBL:SEI79367.1,
RC ECO:0000313|Proteomes:UP000198888};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; FNYR01000008; SEI79367.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H6TQ74; -.
DR STRING; 1073996.SAMN05444271_10855; -.
DR OrthoDB; 146065at2157; -.
DR Proteomes; UP000198888; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000198888}.
FT DOMAIN 686..702
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 826..892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 492..526
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 851..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 612..619
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 908 AA; 98760 MW; 9A80521908A4803C CRC64;
MSQGIVEEFL SIKADSDADL LAMQCGDFYE FFADDAETVS DELDLTVSQK SSHGSSYPMA
GIPLSELTPY MKALVERGYR VAVADQFQDD NGDHYREITR LITPGTLIET TDAEAQYLAA
VVRADGNEGP YGLAFADITT GQFLVTEVDT AADAHAELYR FDPAEVLPGP DVRTDDDFSR
QLRERSDASL ALFDTDAFAP GRSAHTVRDQ FGSETVDSIG LDSELAVRAA GAVLSYVEET
GVGVRQSMSR LQLYTADDHL TLDATTQRNL ELVETMHGDK GGSLLDTIDH TETSPGGRLL
REWLTRPRQD ASELGRRLDC VETLTSAALP RERLRETLDG AYDLERLASQ AASGSADARD
LLAVRDTLEL LPTLADEIAG GQLADSPLST VIDKPDRAAA AELRETLAEA LADDPPKTVT
QGGLFKYGFD DELDDLIERH EEANEWLDGL ADRIKRQYGL SHVTVDRNKT DGYYIQVGKS
QADSVPDSFQ HIKTLKNSKR FVTDELAERE REILRLEESR GELEYERFAE LRDQVAEQSA
LLQDVGRALA EVDVLCSLAS HAAANSWCRP ELTTAGTLDI EAGRHPVVEQ ATEFVPNDLT
LDDKRGFLIV TGPNMSGKST YMRQSALITL LAQVGSFVPA RSTTVGIVDG IYTRVGALDE
LAQGRSTFMV EMQELSNILH SATQDSLVIL DEVGRGTATY DGISIAWAAT EYIHNQIGCH
CLFATHYHEL TALASHLDRV GNVHVAADER DGEITFLRTV QEGATDRSYG IHVADLAGVP
MPVVDRARNV LTKLREEKAI EAKGAASGGE AKQAVFDLSA GEFQTSETNG AATASGAATA
ETDRRESAET TASTRAATHS ESAATEPESV DPAAQEVLAA IESTDINETP PVELMTKVQQ
WQKQLDET
//
