ID A0A1H6V9Q0_9BACT Unreviewed; 602 AA.
AC A0A1H6V9Q0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000256|ARBA:ARBA00015325, ECO:0000256|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000256|ARBA:ARBA00033342, ECO:0000256|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000256|ARBA:ARBA00033245, ECO:0000256|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000256|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000256|HAMAP-Rule:MF_01810};
GN ORFNames=SAMN05216327_10538 {ECO:0000313|EMBL:SEI97022.1};
OS Dyadobacter sp. SG02.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Spirosomataceae;
OC Dyadobacter.
OX NCBI_TaxID=1855291 {ECO:0000313|EMBL:SEI97022.1, ECO:0000313|Proteomes:UP000199631};
RN [1] {ECO:0000313|EMBL:SEI97022.1, ECO:0000313|Proteomes:UP000199631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SG02 {ECO:0000313|EMBL:SEI97022.1,
RC ECO:0000313|Proteomes:UP000199631};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000256|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000256|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01810};
CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01810}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000256|ARBA:ARBA00010527, ECO:0000256|HAMAP-Rule:MF_01810}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FNYL01000005; SEI97022.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H6V9Q0; -.
DR STRING; 1855291.SAMN05216327_10538; -.
DR OrthoDB; 9780552at2; -.
DR Proteomes; UP000199631; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd20070; 5TM_YidC_Alb3; 1.
DR CDD; cd19961; EcYidC-like_peri; 1.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028053; Membr_insert_YidC_N.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR028055; YidC/Oxa/ALB_C.
DR InterPro; IPR047196; YidC_ALB_C.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR NCBIfam; TIGR03593; yidC_nterm; 1.
DR NCBIfam; TIGR03592; yidC_oxa1_cterm; 1.
DR PANTHER; PTHR12428:SF65; INNER MEMBRANE PROTEIN ALBINO3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR12428; OXA1; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR PRINTS; PR00701; 60KDINNERMP.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|HAMAP-Rule:MF_01810};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01810};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01810}.
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 412..435
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 469..490
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 502..522
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT DOMAIN 68..333
FT /note="Membrane insertase YidC N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14849"
FT DOMAIN 349..546
FT /note="Membrane insertase YidC/Oxa/ALB C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02096"
FT REGION 39..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 602 AA; 68151 MW; A638AEBB5FEB7583 CRC64;
MDKNFVIGLV LIMLMLIGYQ VLVPKPVEPT PVAEVKKEAA KPASVTSDTT QKSSQSVDST
AVPQKDLVIE TKDARVVFTN KGGVMKEVML KNYKTYDQKP LYLIAENHNN FQIDLPTQTG
DVRLTNQTFT TDAQDRTLAE KDSAVITYRT TLKNNQTVEQ TYLVRGSGYV IDYGIKASGA
LPANKSVEFH WDNDLLQLEN DMKKNREVVT VNYYTDALKS LPTSPTSNEE EKTADPVKWF
TIKHKYFLAG LIAEKTPLTN VTMRANVNVE DSVIVKNMNI FAGIPAAAVQ KGEANFQFYL
GPNEYHIVDK VKAENFDQNV YLGYAFLKPI NKFFLVPLFN LIEGFVSNYG LLIILLVLFV
KTLLTPLTYK SYISMAKMRI LGPELEQIRE ANKDDVAKQQ QEQMKLYQQV GVSPLSGCVP
VLATMPILFS LFFLFPNLIE LRQQSFLWAS DLSTYDSFFK LPFNVPFGIG NHISLFTILM
TASSIGYAYY NNQNTPTQPG PVNMKALGYV MPLMFMFILN SFPAGLTFYY FVSNVVTIAQ
QLLIKRFVNE DKIKNILEEN RKKNATGEKK QNKFQKYLEK SLQAAEEAKK KQAELEKKTK
KK
//
