ID   A0A1H6WE87_9GAMM        Unreviewed;       264 AA.
AC   A0A1H6WE87;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   SubName: Full=Steroid 5-alpha reductase family enzyme {ECO:0000313|EMBL:SEJ10822.1};
GN   ORFNames=SAMN04487997_2539 {ECO:0000313|EMBL:SEJ10822.1};
OS   Frateuria terrea.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC   Rhodanobacteraceae; Frateuria.
OX   NCBI_TaxID=529704 {ECO:0000313|EMBL:SEJ10822.1, ECO:0000313|Proteomes:UP000199420};
RN   [1] {ECO:0000313|EMBL:SEJ10822.1, ECO:0000313|Proteomes:UP000199420}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 26515 {ECO:0000313|EMBL:SEJ10822.1,
RC   ECO:0000313|Proteomes:UP000199420};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; FNYC01000004; SEJ10822.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H6WE87; -.
DR   STRING; 529704.SAMN02927913_3114; -.
DR   OrthoDB; 9779233at2; -.
DR   Proteomes; UP000199420; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   Gene3D; 1.20.120.1630; -; 1.
DR   InterPro; IPR001104; 3-oxo-5_a-steroid_4-DH_C.
DR   InterPro; IPR010721; UstE-like.
DR   PANTHER; PTHR32251; 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; 1.
DR   PANTHER; PTHR32251:SF15; 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295); 1.
DR   Pfam; PF06966; DUF1295; 1.
DR   PROSITE; PS50244; S5A_REDUCTASE; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199420};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        28..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        104..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        191..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          139..218
FT                   /note="Steroid 5-alpha reductase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50244"
SQ   SEQUENCE   264 AA;  30065 MW;  46C925094463B771 CRC64;
     MPWCTLLLVW LLASAIMAAG WRWQRRHANA GIVDVLWAAG LAGAALLLCV LGPGAAAPRM
     LAGLLGSVWG ARLGWHLWRR VRHEPEDGRY RALREHWRGD QRRLFGFFQL QAIAITLFAL
     PFAAVAANRH THAPWLVVGA ATWLLGVGGE SLADAQLARF RADPAQRGRT CRTGLWRWTR
     HPNYFFEWLH WFAYVAFAVG SPLAWLAWSG PLLMYLFLRY VSGIPYTEAQ ALRTRGADYR
     AYQRDTSMFF PWFPRHPTES RTDP
//