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Database: UniProt
Entry: A0A1H6WSZ4_9ACTN
LinkDB: A0A1H6WSZ4_9ACTN
Original site: A0A1H6WSZ4_9ACTN 
ID   A0A1H6WSZ4_9ACTN        Unreviewed;       440 AA.
AC   A0A1H6WSZ4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   13-FEB-2019, entry version 6.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   ORFNames=SAMN05443287_103154 {ECO:0000313|EMBL:SEJ15622.1};
OS   Xiangella phaseoli.
OC   Bacteria; Actinobacteria; Micromonosporales; Micromonosporaceae;
OC   Xiangella.
OX   NCBI_TaxID=1144548 {ECO:0000313|EMBL:SEJ15622.1, ECO:0000313|Proteomes:UP000198707};
RN   [1] {ECO:0000313|EMBL:SEJ15622.1, ECO:0000313|Proteomes:UP000198707}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.7038 {ECO:0000313|EMBL:SEJ15622.1,
RC   ECO:0000313|Proteomes:UP000198707};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
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DR   EMBL; FNYV01000003; SEJ15622.1; -; Genomic_DNA.
DR   BioCyc; GCF_900109115:BMY89_RS09035-MONOMER; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000198707; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR016204; HDH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000198707};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR000098-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN      356    435       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   NP_BIND      10     17       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   ACT_SITE    207    207       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000098-1}.
FT   BINDING     107    107       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   BINDING     192    192       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000098-2}.
SQ   SEQUENCE   440 AA;  44799 MW;  7B8B1B9A7C4905DA CRC64;
     MTSPVRLALL GCGTVGAEVV RLLHEQSTDL AARIGAPLEI AGIAVRRIGR DRGDLPIDPA
     LFTTDALGLI KRDDVDVVVE VVGGIEPARG WLVEALRAGK SVVTANKALL AEDGGALHDA
     AVEGGGDLYY EASVAGAIPL LRPLRESLHG DRITRVTGIV NGTTNFILSA MHATGAGFAE
     ALEEATELGY AEADPTADVE GFDAAAKAAI LASLAFHTRV GAADVHREGI TEVTAADVAS
     AKAMGCTIKL LCIAARGADG QGQETVSVRV HPAMIPLTHP LASVGDAFNA VFVEAEAAGQ
     LMFYGRGAGG APTASAVLGD VVAVARNRLA GVRAASESAY ADLPVRPMGE ALTRYHISLD
     VADRPGVLES VAGVFARHDV SIATVRQGPA GGSAGGAGEA VLVIVTHVAP DAALAATVQE
     LRGLDIVRSV ASVLRVEGGL
//
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