ID A0A1H6XRV8_9SPHN Unreviewed; 412 AA.
AC A0A1H6XRV8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Membrane fusion protein, multidrug efflux system {ECO:0000313|EMBL:SEJ30916.1};
GN ORFNames=SAMN05428950_1011794 {ECO:0000313|EMBL:SEJ30916.1};
OS Sphingomonas sp. OV641.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=1881068 {ECO:0000313|EMBL:SEJ30916.1, ECO:0000313|Proteomes:UP000199191};
RN [1] {ECO:0000313|Proteomes:UP000199191}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OV641 {ECO:0000313|Proteomes:UP000199191};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FNZB01000001; SEJ30916.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H6XRV8; -.
DR STRING; 1881068.SAMN05428950_1011794; -.
DR OrthoDB; 9811754at2; -.
DR Proteomes; UP000199191; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR PANTHER; PTHR30386:SF24; MULTIDRUG RESISTANCE EFFLUX PUMP; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199191};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 49..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..386
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 90..333
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 131..179
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 412 AA; 44688 MW; E384D174140C11D6 CRC64;
MADDRAENHE NKVRHDDPDA NFHPESRSED GSEEMNGEKK PSLLERYPII RYVLIAALVA
GIIAAIVWYM NYRASGQFLQ STNNAYVRAD FVTVSPKVGG YVERVLVADN QPVRRGQLLA
VLDPRDYRAN VEEAQAQIAA AGANITTARR TLDEQQATVA QAAAQVASAE AAAAAAENEV
RRYEPLTRTG AESRERLASL VLQRDRAAAE LRAQRAAYLA ARRSVATQAA RIGQAEAQRG
TAQAQLARAS TDLGAVEIRS SIDGVVADKA VRAGQYVQPA TRLMSVVPVD QLYIEANFKE
TQVALMRVGQ PVTIKVDALD GAELRGRVAS FSPGTGAQFS LIPPENATGN FTKIVQRVPV
RISIEAGPEA RRVLRPGLSV EVTVDTIGAK GSRERIKQET ERLKRGETQG AR
//
