ID   A0A1H6Y4A3_9MICO        Unreviewed;       327 AA.
AC   A0A1H6Y4A3;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Cation:H+ antiporter {ECO:0000313|EMBL:SEJ31960.1};
GN   ORFNames=SAMN05421637_1398 {ECO:0000313|EMBL:SEJ31960.1};
OS   Demequina mangrovi.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Demequinaceae;
OC   Demequina.
OX   NCBI_TaxID=1043493 {ECO:0000313|EMBL:SEJ31960.1, ECO:0000313|Proteomes:UP000183315};
RN   [1] {ECO:0000313|Proteomes:UP000183315}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 24868 {ECO:0000313|Proteomes:UP000183315};
RA   Varghese N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; FNZI01000003; SEJ31960.1; -; Genomic_DNA.
DR   RefSeq; WP_042214953.1; NZ_FNZI01000003.1.
DR   AlphaFoldDB; A0A1H6Y4A3; -.
DR   STRING; 1043493.SAMN05421637_1398; -.
DR   eggNOG; COG0530; Bacteria.
DR   OrthoDB; 9794225at2; -.
DR   Proteomes; UP000183315; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR   InterPro; IPR004481; K/Na/Ca-exchanger.
DR   InterPro; IPR004837; NaCa_Exmemb.
DR   InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR   NCBIfam; TIGR00367; calcium/sodium antiporter; 1.
DR   PANTHER; PTHR10846:SF8; INNER MEMBRANE PROTEIN YRBG; 1.
DR   PANTHER; PTHR10846; SODIUM/POTASSIUM/CALCIUM EXCHANGER; 1.
DR   Pfam; PF01699; Na_Ca_ex; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000183315};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        38..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        74..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        177..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        213..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        242..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        279..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        309..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          4..144
FT                   /note="Sodium/calcium exchanger membrane region"
FT                   /evidence="ECO:0000259|Pfam:PF01699"
FT   DOMAIN          178..322
FT                   /note="Sodium/calcium exchanger membrane region"
FT                   /evidence="ECO:0000259|Pfam:PF01699"
SQ   SEQUENCE   327 AA;  33322 MW;  AD83A2B3330B5D22 CRC64;
     MTAAILATLL GLVALGWSAD RFVSGASAVA THLGMAPLLV GMVVVGFGTS APELVVSAFA
     SADGNPEIAL GNALGSNIAN IGLILGTTAI LVPVVVHRGV LSRELPILVG ATVLLAAVML
     DGRISRIDAA VLVAALGAQL LWSIRAGTRR RAPGEPEDEL AIEVEERERA AGMSRRAAWA
     WTVGGIVLLV AASRVLVWGA VQIADRLGWS DLVIGLTVVA IGTSAPELAA AIAAARRRAT
     ELVLGNVIGS NLFNTLAVVG LAGLIAPSAV EPQALSRDLP VLLAMTLAML VMGFRPGGHG
     RINRYEGGAL LAAWIAYTAL LLATAGG
//