ID A0A1H6Z6Y1_9ACTN Unreviewed; 3986 AA.
AC A0A1H6Z6Y1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:SEJ45392.1};
GN ORFNames=SAMN05443287_104486 {ECO:0000313|EMBL:SEJ45392.1};
OS Micromonospora phaseoli.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=1144548 {ECO:0000313|EMBL:SEJ45392.1, ECO:0000313|Proteomes:UP000198707};
RN [1] {ECO:0000313|Proteomes:UP000198707}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.7038 {ECO:0000313|Proteomes:UP000198707};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC family. {ECO:0000256|ARBA:ARBA00029443}.
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DR EMBL; FNYV01000004; SEJ45392.1; -; Genomic_DNA.
DR STRING; 1144548.SAMN05443287_104486; -.
DR OrthoDB; 5478077at2; -.
DR Proteomes; UP000198707; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 3: Inferred from homology;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 585..662
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 678..1089
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1941..2019
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3017..3092
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 550..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1477..1497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1613..1635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1652..1677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1902..1944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2604..2631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2990..3020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3095..3134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3331..3359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3501..3520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3584..3604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1906..1925
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3004..3019
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3333..3352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3986 AA; 417046 MW; 6B849515B73A6C01 CRC64;
MQTATGSGGQ RTLLDVLLDA ADRRPDQVVV HLREDGTERT VTVRELRDES LRVAGGCHAA
GIAPGTPAIL LADAGDDFQP MFWGTLAAGL IPVPLPPEPS RVRAVRDLLT DAVVVTDDAT
ATTVDGLPGP VLRLAALRAG TPPDELPRRT PDDVAFLQFS SGSTGAPRGV ELTHANVLSN
VEQARLASGA RPDDVLVTWM PFFHDMGLIG THLTPLAIGC KQIRIPPLAF AKRPALWFTA
AHRHRATLLS AANFALAMAV RRVPADTLAA LDLSRVRCLV VGAEPISAAV WRAFLDHTRA
AGLDPAAPRP VYGLAEATLA VTFPPAGEVA APLVLDRAAL SLGRAVPTQP GGHAVELMDL
GHPVHGCEIR VVDDRHRPVV ENRVGLIEVR GPNVARGYHR APQASRETFV DGWLRTGDLG
FLRAGRLCVT GRAKDVVFVN GRTFHAPDLE AVAAATPGLP TGVTAVVGCT DPDSGGERIV
VFVAWARPPA GAAGVLDATR ARVAEAAGHH DVRVLPLPPG AFARTTSGKL RRRRMRDRYL
AGDFADREHR WHPPAPVTVP APASTAAEPP ATTPAGPPTG DPWRLPRREV ERIVRTVWAG
VLDRPADTIG LDDRFLAIGG SSLKAMEVLA GLEDALSTTF APADLRDCPT VATLTDRILA
GPGVAPTRPA AAPTGGYAAP MAVIGMACRF PGADDPDQFW RRLVDGVDEV RPVPAHRWTP
QGDHPRWGSF LDDPMLFDAE FFGLTESEAR LTDPHARLFL EIGYEALERA GYAGPRRQGR
RIGVFAAVGD SAYPELLAAD GPVAAPAALV GNLRNLVAAR LAQTLDLTGP AIAVDTACSS
ALVALHLAAR SLAAGECDIA VVGGVNLNLT ETAYRLLDAA EALSPTGRCR AFDADADGFV
PGEGGAALVL CRPADAHAAA DPVLALVTGT AVGNDGRSLS LLAPNPHRQW EVIARAYADA
GIDPAAVSYI EAHGTGTGIG DPVEARSLAA AFPPRPDGTP RWLGSVKTNL GHLLNTAGMP
ALLKVVLALR HRQLPPSLHH VRPSTRYDLD ATGFAVVTAT RPWSAPGPLV AGVNAFGFGG
TNAHAVLSEA PRRPPTPAPA DGHVGGQLVT LTAHSAPALR RSARDLAQHL RAHPELAAAD
VAASASTARD DAPYRLALVA TADLADRLEE AADTLADAPV RRRPRTVFVF PGDGTPVPAP
VVRDLHARLP VFRGLLTDAC AAAGPLAGRP LLSWCLAEDT PADRDRPDRQ VTATVGVVVA
LALAGQLTAW GVRPDAVLGH GVGELAAAAA SGTLSVAEAV RRTVALTGTE PGGPADETVR
VEMRAALRRL LDDGYDTVVE LGPAGDAARS FDGRAAGPVR VVTLLDAPAH PADAGATSLL
TAVGGLWSRG GPLDRLALHV GRRRVPVPTY PFERRAYPPP AAAEAAVPLY LPAWREVPPV
AGDRPPTVRL RGPGVDGRFA AALTTALTAD GIEVHTGEPE TAVPPTGRGS ITARPGDGAS
TAEVTVLLAG AAVDPPDATA LDAAVADQVR AVRALLDEGL DHPGRLLVVT EDVHVTGSAA
ERPRPVQAVL AGLTTALADE RPGLLVRPVD LSSLDGEAAR VDAVRREVRG FVDSGTSDTG
RRAGATGPQG APPGPVAAIG VAWRNGRRLA RFLDPAPTST DPTSDGPGMT GDARRPGAGG
VHLIVGGAGG VGAALARTLA RADRPTLLLA GRSDRAPAEL LTELTELGAA VTYHRCDVTV
AADVDALLAG APRLDTVFHA AGTVRVGTLR VKSTRDVLAV LAPKVRGSYL LTEALRRHRH
DRAALVGFSS VSAVLPGLAG AIGDYAAANA FLDAFAAAHR AAGRRVQAVG FAAITDIGMA
ARTGGTGTGA LPVRDALRAL ALARRLDAAH LVVADLRRRA DPHAPASTAP TSTAPTSTTP
ASTAVAGRTA GRPRPDAAHD GPNRDEVARL LRRLLAEPLH RRPDEIADDA SFLALGLDSL
AAVDLVKRLE EEIGRDLPVT LFFEYTTVAE LAAHLTATTD AASPPAACTV EQPAPVHEPG
PRPSAHGEPF PLTAVQRAFH VNERLHPTVA SYAFVQQTIT GTIDATLLGR ALAHLETQHP
MLRVRFVPGT GAGTPRQVIL PPTEQPAPAW YAVQPLTGPL GALAERLCNT PVDLTRQPPL
RAVLVRETPD RAHLLLVQHH AAGDGFSLNL LSEELWSGYT ALCHGRTPPP SPAPGFDAYA
RAVTPPTAQD LSYWQDRLSG DGWTLPLPYD GDRAAPPAPP YLTHQGDLDA DLVAALRDRA
AAAGVSLFHL LLAGYVRCLS RWSGQQSVPV TVARAGRDAR LPAIGRIVGP FADTLPLRID
TDPDEPTGQL ADRLRVAWSA AQRHGSVTSL DLARLLDRPG AGPRTASPAG FSFARFPVTR
DPDCPVTVTP TAAGSASAAT RLSLLCWESG AGLGLSWNFP LRLFTRATVA RLAAEHRQEL
VALAAGRRQP AQPGAAAGGD VTARIRAVCR RTPDAVAVDT GDGSLTYRAL DLAADRVAGL
LTRQGVRPGD RVGLLTAPGP QTVVGVVGIL RAGAAWVPLD AAHPPARLTD HLVRAGAELL
LHDDECAATA AGLVHAARPI RLAPPTSDSA ADATTDSGTG PQAPPPAPEH PAYVIFTSGS
TGRPKGVPVT HRSMSTYLDW AIASFGYRPT DRLAQTSSSC FDASVRQILA PLLVGATVVT
FTRSLLRDPQ ALLSRIERDR ITVWSSVPTL WERILHAAEE HVARHGVAPD LTALRWVHVG
GEELSPVPVR RWFDLFGDDC RITNLYGPTE ATINATWHLI DRRPDDAVRR LPIGRPVGAA
VVHVVDPAGR TCPPGVAGEL YLGGVGLTAG YLGEPELTDA AFVVREGQRF YRSGDRGRVA
ADGTLEFLGR LDDQVKIHGY RVEPGEIEAV LRTHPAVAAA AVLHQADPHP RLHAFVLPTS
QSTPTVADLR AHLAARLPEH MVPARLQLLD SLPLTATGKI DRARLLAHTG TRPATAREHA
ATTTGPHPAT TTGPVTGPVS GTEASLARIW ADLLDVPAVG PDDDFFALGG DSILILEVFA
QLRERFPTAL RPTAIYEHRT LAALAAAIDT AADPASGSAG PAAGLSPAPA TPGPSFCAPA
AGQPAPDTSP AGPFPVTATQ RGFLLADAVV PGAGTAWLAR LRLHGRLRRD IFQRAVDLLV
ARHPMLRTVF PAGARPPVQQ ELPVSMRLPV EYETLAQHSD VAARVAEERR RRFEPWAWPL
LRLRLLTVTP DEHVLLVHAH HLIGDGYSAA LLGHELLAAY HRQADGSPDP LPPLRTSFRD
YVTLLERRST AAPDPAARAW WARRFGPPYR PPVRRADTDR SPDADRPEAD GAPGQRTRSA
PVRGFTLDLT VVAGLRRLAA EAASTLYAPV LTAYHRALAR LTSQDDLVVG LAVTGRDHPL
PDLHRVFGPC AAMLPLRLTG TAAFPTHLAH VAAEVAAARQ HADPPSIAAA VPTGRPDGAP
TGAQFFFSFL DFDALDPVLA LGSADDPPPA APSGHTGSAA PTRLRLTWDE ETELAPPPIG
TDLFLTARPG PDGLRVTLRG SPTAVSPTDL DRLVDWLRTD LTTAAAEQSR RGTPERPDPN
LATAPAVVPS TRLTAAIVGY LPPPAQLAAI AGLPAGSLPR EQLRELLFPA GRPRLLEELT
TPLGTSGFVC LPRFSDELTA AGETLAAETA AAVDLAATLG AACVSLAGLI PAHTGYGIGV
LRRTRTATAI TTGHAATVVS VVLTVEAALA ASGRHLAGST LAVVGLGSIG FSSLRLLLAR
APRPPARLVL CDIPSAAPRL RDQANRLRSD GFAGTVEICA TTSTVPDPGY AADLIIGATS
AATEPLDVDR LRPGTIVVDD SFPHALNPVR ALARMRHDRD VLVVGGGLLH VAETTRTVPA
DLPPAAIAGH AAGFGLPGAV ASCQLESLLR AASPTLPVVH GLVDDSTAAT YAQALTEAGI
GAAPLHLLHQ LVDADLPAAL PAGPPA
//
