ID A0A1H6ZVA1_9BACT Unreviewed; 384 AA.
AC A0A1H6ZVA1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=2-isopropylmalate synthase {ECO:0000256|ARBA:ARBA00012973};
DE EC=2.3.3.13 {ECO:0000256|ARBA:ARBA00012973};
GN ORFNames=SAMN04487995_5382 {ECO:0000313|EMBL:SEJ57271.1};
OS Dyadobacter koreensis.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Spirosomataceae;
OC Dyadobacter.
OX NCBI_TaxID=408657 {ECO:0000313|EMBL:SEJ57271.1, ECO:0000313|Proteomes:UP000199532};
RN [1] {ECO:0000313|EMBL:SEJ57271.1, ECO:0000313|Proteomes:UP000199532}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19938 {ECO:0000313|EMBL:SEJ57271.1,
RC ECO:0000313|Proteomes:UP000199532};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine
CC from 3-methyl-2-oxobutanoate: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004689}.
CC -!- SIMILARITY: Belongs to the alpha-IPM synthase/homocitrate synthase
CC family. {ECO:0000256|RuleBase:RU003523}.
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DR EMBL; FNXY01000009; SEJ57271.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H6ZVA1; -.
DR STRING; 408657.SAMN04487995_5382; -.
DR OrthoDB; 9804858at2; -.
DR Proteomes; UP000199532; Unassembled WGS sequence.
DR GO; GO:0046912; F:acyltransferase activity, acyl groups converted into alkyl on transfer; IEA:InterPro.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0009082; P:branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd07940; DRE_TIM_IPMS; 1.
DR Gene3D; 1.10.238.260; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR002034; AIPM/Hcit_synth_CS.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR000891; PYR_CT.
DR PANTHER; PTHR10277:SF9; 2-ISOPROPYLMALATE SYNTHASE 1, CHLOROPLASTIC-RELATED; 1.
DR PANTHER; PTHR10277; HOMOCITRATE SYNTHASE-RELATED; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS00815; AIPM_HOMOCIT_SYNTH_1; 1.
DR PROSITE; PS00816; AIPM_HOMOCIT_SYNTH_2; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Branched-chain amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023304};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Reference proteome {ECO:0000313|Proteomes:UP000199532};
KW Transferase {ECO:0000256|RuleBase:RU003523}.
FT DOMAIN 5..266
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
SQ SEQUENCE 384 AA; 41878 MW; 78A548F7E032AB4C CRC64;
MSQRVQIFDT TLRDGEQVPG SQLTTEEKII VATQLEKLGV DVIEAGFPIS SPGDFRSVVE
ISKAVREPII CALSRAVTGD IDAAGDALAF AKRGRIHTGI GSSDIHIQHK FNTTREKIIE
RAIAATKYAK GKVEDVEFYC EDAGRADLVF LAQLVEAVIA AGATVVNIPD TTGYCLPEEY
GAKIKYIFEN VKGIHNATIS IHCHNDLGLA TANSLAGIRE GARQVEVTMN GIGERAGNTS
LEEVVMALNV HKELGYETGV NSQLIYPTSQ LVSKMMRMPV QANKAIVGRN AFAHSSGIHQ
DGHLKNTLNY EIMNPQDVGV DKSDIVLTAR SGRHALKHRL ELLGFTFEKV ILDDLYKKFL
DVADLKKEVN DKDLVDLART VVIA
//
