ID A0A1H7A940_9FIRM Unreviewed; 367 AA.
AC A0A1H7A940;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Tyrosine lyase ThiH {ECO:0000313|EMBL:SEJ62101.1};
GN ORFNames=SAMN05660742_11212 {ECO:0000313|EMBL:SEJ62101.1};
OS Propionispira arboris.
OC Bacteria; Bacillota; Negativicutes; Selenomonadales; Selenomonadaceae;
OC Propionispira.
OX NCBI_TaxID=84035 {ECO:0000313|EMBL:SEJ62101.1, ECO:0000313|Proteomes:UP000199662};
RN [1] {ECO:0000313|EMBL:SEJ62101.1, ECO:0000313|Proteomes:UP000199662}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 2179 {ECO:0000313|EMBL:SEJ62101.1,
RC ECO:0000313|Proteomes:UP000199662};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; FNZK01000012; SEJ62101.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H7A940; -.
DR STRING; 84035.SAMN05660742_11212; -.
DR Proteomes; UP000199662; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR010722; BATS_dom.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR012726; ThiH.
DR InterPro; IPR034428; ThiH/NoCL/HydG-like.
DR NCBIfam; TIGR02351; thiH; 1.
DR PANTHER; PTHR43583; 2-IMINOACETATE SYNTHASE; 1.
DR PANTHER; PTHR43583:SF1; 2-IMINOACETATE SYNTHASE; 1.
DR Pfam; PF06968; BATS; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00301; 2-iminoacetate_synthase_(ThiH); 1.
DR SFLD; SFLDG01081; cleavage_of_the_Ca-Cb_bond_in; 1.
DR SMART; SM00876; BATS; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Lyase {ECO:0000313|EMBL:SEJ62101.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000199662};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 256..358
FT /note="Biotin and thiamin synthesis-associated"
FT /evidence="ECO:0000259|SMART:SM00876"
SQ SEQUENCE 367 AA; 41812 MW; B610864DD16545DD CRC64;
MSFLQEMEKY KDLDLPEFFS KIKDQDVLSA LRKEKLNCYD YLTLLSPAAE SHLEAMAQRA
RRMTIQNFGK VMQLFTPMYI ANYCDNLCVY CGFNHDNVLE RKQLTMAEVE AEAQKISETG
LKHILILTGE SQKYSSIEYI LAAVQILKKF FTSISVEIYS LTEEEYVRAV QSGVDGMTMF
QEVYDSSIYK ELHLAGPKSI YEFRLDAPER ACRAGMRNVN IGALLGLNDW RKEAFFTGVH
ADYLQHAYKD VEVAVSTPRM RPCAAGFSPR VIVNDVNLVQ YITAYRIFMP RSGITLSSRE
SRMMRDHLVK LGVTKISGGV TTAVGGHTKG EDSSQFDISD TRSIEDMAQM LYSEGYQPVY
KDWQGLY
//
