ID   A0A1H7B0F5_9BACT        Unreviewed;       452 AA.
AC   A0A1H7B0F5;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=Alanine or glycine:cation symporter, AGCS family {ECO:0000313|EMBL:SEJ70666.1};
GN   ORFNames=SAMN05192553_10931 {ECO:0000313|EMBL:SEJ70666.1};
OS   Cyclobacterium xiamenense.
OC   Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae;
OC   Cyclobacterium.
OX   NCBI_TaxID=1297121 {ECO:0000313|EMBL:SEJ70666.1, ECO:0000313|Proteomes:UP000199403};
RN   [1] {ECO:0000313|Proteomes:UP000199403}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBRC-M 10761 {ECO:0000313|Proteomes:UP000199403};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363064};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU363064}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the alanine or glycine:cation symporter (AGCS)
CC       (TC 2.A.25) family. {ECO:0000256|ARBA:ARBA00009261,
CC       ECO:0000256|RuleBase:RU363064}.
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DR   EMBL; FNZH01000009; SEJ70666.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H7B0F5; -.
DR   STRING; 1416801.SAMN05192553_10931; -.
DR   Proteomes; UP000199403; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005283; F:amino acid:sodium symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR001463; Na/Ala_symport.
DR   NCBIfam; TIGR00835; agcS; 1.
DR   PANTHER; PTHR30330; AGSS FAMILY TRANSPORTER, SODIUM-ALANINE; 1.
DR   PANTHER; PTHR30330:SF3; TRANSCRIPTIONAL REGULATOR, LRP FAMILY-RELATED; 1.
DR   Pfam; PF01235; Na_Ala_symp; 1.
DR   PRINTS; PR00175; NAALASMPORT.
DR   PROSITE; PS00873; NA_ALANINE_SYMP; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU363064};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363064};
KW   Symport {ECO:0000256|RuleBase:RU363064};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363064}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        65..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        93..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        145..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        186..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        243..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        301..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        353..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        419..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
SQ   SEQUENCE   452 AA;  48861 MW;  E60548BE884A837C CRC64;
     MGELIIAFSN WIWGTPLLIL LMGGGFFMLL YSRLIPFRGL RHAMKVVGGK YDDPNASGDI
     TSLQALSSAI AATVGLGNIS GVALAIGTGG PGAIFWMWVS AFVGMATKFF TCTLAIMYRG
     KDSSGHIQGG PMYVIEEGMG KKWRFLSVIF CVAGIMGLLA IFQANQLTEV LRVVLLRPFG
     LDWGQTSRWI IGVTVMLLVA LVILGGIQRI AKVASRLVPF MVSMYFVCVF IILFKNLGEV
     PSMILYIIED AFTGKAVLGG AVGQVIIIGA RRAAFSNEAG IGTAPMVHGA SKTSEPVREG
     LIAMLGPFID TIVVCTLTAL VILVTGVWKS GERDGVLLTL SAFEQGLPGI GKYLLMAAVL
     IFALSTMFTY SYYGHKCFNY LFGADKADYY NYFYLITIVG GAVTSLSVVM SFVDGMYAVM
     AFPTMISALY LSPKVIAATK DYFERMKLLD EK
//