ID A0A1H7C894_9ACTN Unreviewed; 509 AA.
AC A0A1H7C894;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=4-hydroxyphenylacetate 3-monooxygenase {ECO:0000313|EMBL:SEJ81865.1};
GN ORFNames=SAMN05443287_10874 {ECO:0000313|EMBL:SEJ81865.1};
OS Micromonospora phaseoli.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=1144548 {ECO:0000313|EMBL:SEJ81865.1, ECO:0000313|Proteomes:UP000198707};
RN [1] {ECO:0000313|Proteomes:UP000198707}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.7038 {ECO:0000313|Proteomes:UP000198707};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FNYV01000008; SEJ81865.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H7C894; -.
DR STRING; 1144548.SAMN05443287_10874; -.
DR OrthoDB; 9785230at2; -.
DR Proteomes; UP000198707; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR Gene3D; 1.10.3140.10; 4-hydroxybutyryl-coa dehydratase, domain 1; 1.
DR Gene3D; 2.40.110.10; Butyryl-CoA Dehydrogenase, subunit A, domain 2; 1.
DR Gene3D; 1.20.140.10; Butyryl-CoA Dehydrogenase, subunit A, domain 3; 1.
DR InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR InterPro; IPR036250; AcylCo_DH-like_C.
DR InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom_sf.
DR InterPro; IPR024677; HpaB/PvcC.
DR InterPro; IPR004925; HpaB/PvcC/4-BUDH.
DR InterPro; IPR024719; HpaB/PvcC/4-BUDH_C.
DR InterPro; IPR024674; HpaB/PvcC/4-BUDH_N.
DR PANTHER; PTHR36117; 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE-RELATED; 1.
DR PANTHER; PTHR36117:SF3; 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE-RELATED; 1.
DR Pfam; PF03241; HpaB; 1.
DR Pfam; PF11794; HpaB_N; 1.
DR PIRSF; PIRSF500125; 4_HPA_large; 1.
DR PIRSF; PIRSF000331; HpaA_HpaB; 1.
DR SUPFAM; SSF47203; Acyl-CoA dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF56645; Acyl-CoA dehydrogenase NM domain-like; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR000331-2};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Monooxygenase {ECO:0000313|EMBL:SEJ81865.1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 9..274
FT /note="HpaB/PvcC/4-BUDH N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11794"
FT DOMAIN 282..482
FT /note="HpaB/PvcC/4-BUDH C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03241"
FT BINDING 150..152
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000331-2"
FT BINDING 191
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000331-2"
SQ SEQUENCE 509 AA; 56649 MW; F61E2A28E3ADC540 CRC64;
MSPETRPLTG DEYVETLRDG RAVYLYGERI RDVTRHPAFH NPIRMTARLY DALHSDEHRS
VLTTACDAPG SQGYTHWFFT TPRSAEDLVA AERAIATWAR MSYGWLGRGP DYKASFLGTL
GANADFYQPF ADNARHWYRL SQERVLYWSH AIVHPPVDRS RRPDQVADVF VHVERETDAG
LVVSGAKVVA TGAALTHHTF VAHYGLPVAR REFALVAAVP TDAPGVKLIC RPSYAATANV
LGSPFDYPLS SRLDENDTIL VLDKVLIPWE NVFVYGDLAK VQTFAGRSGF TERFTFHGCV
RLAVKLEFLA GLLAKALETT GTADFRGVQS RLGEVLAWRN MFQGLAGAAA RDPVPWHDGS
VLPNPRYGAA YRWFMQVGYP RVREIVLQDV ASGLIYVNSG AEDFANAEIR PYLDRYLRGS
QGIEAVERVK VMKLLWDAVG SEFGGRHELY ERNYAGNHEN TRVELLSAAI ADGDLAGCKA
LVDTCLAEYD LTGWRVPDLS SYEAPRPPH
//
