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Database: UniProt
Entry: A0A1H7CM62_9FIRM
LinkDB: A0A1H7CM62_9FIRM
Original site: A0A1H7CM62_9FIRM 
ID   A0A1H7CM62_9FIRM        Unreviewed;       341 AA.
AC   A0A1H7CM62;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN   ORFNames=SAMN05660742_12325 {ECO:0000313|EMBL:SEJ90768.1};
OS   Propionispira arboris.
OC   Bacteria; Bacillota; Negativicutes; Selenomonadales; Selenomonadaceae;
OC   Propionispira.
OX   NCBI_TaxID=84035 {ECO:0000313|EMBL:SEJ90768.1, ECO:0000313|Proteomes:UP000199662};
RN   [1] {ECO:0000313|EMBL:SEJ90768.1, ECO:0000313|Proteomes:UP000199662}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 2179 {ECO:0000313|EMBL:SEJ90768.1,
RC   ECO:0000313|Proteomes:UP000199662};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; FNZK01000023; SEJ90768.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H7CM62; -.
DR   STRING; 84035.SAMN05660742_12325; -.
DR   Proteomes; UP000199662; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   NCBIfam; TIGR00331; hrcA; 1.
DR   PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR   PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000199662};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW   Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW   Rule:MF_00081};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW   Rule:MF_00081};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW   Rule:MF_00081}.
FT   DOMAIN          2..72
FT                   /note="Winged helix-turn-helix transcription repressor HrcA
FT                   DNA-binding"
FT                   /evidence="ECO:0000259|Pfam:PF03444"
FT   DOMAIN          104..322
FT                   /note="Heat-inducible transcription repressor HrcA C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01628"
SQ   SEQUENCE   341 AA;  38587 MW;  5304AEA22FBB5AC0 CRC64;
     MLDERKQRIL QAIINDYIST AEPIGSRTIA RKYDLGVSSA TIRNEMADLE LLGYIEQLHT
     SSGRIPSSKG YRFYVDDLLI PTTMTENEIT LIRNWYKAKV KRVEEVFQET AKLISRMTKN
     VSLVLAPQLS QAAFRCLQFL PLDAKRVIVV IMTDAGFIEN KIIFVPSGAA FEDFQRMALV
     INKHLMGHTM DSITTATLRK IRDDIMDTSL FDAAMDVIDK ALMVDKKERI YLGGTTQLLN
     QPEFRDVEKV KNILLMLEEE QLLCDILHSN TNHGLSVSIG HENKYSGIQD CSIISATYHL
     DGELLGTIAV LGPTRMEYGK TIALLDFMNE NLSQVLQEFG W
//
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