ID A0A1H7FZH4_STRJI Unreviewed; 1149 AA.
AC A0A1H7FZH4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SAMN05414137_101419 {ECO:0000313|EMBL:SEK29912.1};
OS Streptacidiphilus jiangxiensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptacidiphilus.
OX NCBI_TaxID=235985 {ECO:0000313|EMBL:SEK29912.1, ECO:0000313|Proteomes:UP000183015};
RN [1] {ECO:0000313|Proteomes:UP000183015}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45096 / BCRC 16803 / CGMCC 4.1857 / CIP 109030 / JCM 12277
RC / KCTC 19219 / NBRC 100920 / 33214
RC {ECO:0000313|Proteomes:UP000183015};
RA Varghese N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FOAZ01000001; SEK29912.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H7FZH4; -.
DR STRING; 235985.SAMN05414137_101419; -.
DR eggNOG; COG0210; Bacteria.
DR eggNOG; COG2887; Bacteria.
DR Proteomes; UP000183015; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000183015}.
FT DOMAIN 17..415
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 416..730
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 331..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..368
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 38..45
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1149 AA; 124262 MW; 04D9329F48CFA2EB CRC64;
MPGRLTSPEE LRELLGIPFT AEQLRAITAP LAPAVIVAGA GSGKTTVMAA RVVWLVGTGQ
VRPEQVLGLT FTNKAAAELA ERVRKALLHA GVVETERVEP SAQAGGDEFG EPEISTYHAF
AGRLLTDHGL RIGLEPDVRL LADATRFQLA ARVLRQAPGP YPGLKDGVSS LIAKLVKLDG
ELAEHLVPPE RLITHDTELL ASLAGVKLGN ESLRAVPVAA EARRELAELV VRYRARKREA
QLMDFGDQIA ACARLALTRP EVGGLLREQF AVVLLDEYQD TSVAQRLMLA SLFGDGTGHP
VTAVGDPCQA IYGWRGASVA NLDEFPHHFR EADSDRSREA DRDRSREADR DRSREADPTY
RREADAARSL GAEPPVAAHD VGVADADARA DDAAPRGVQG APAARYSLSE NRRSGGRLLA
FANDLAAPLR AMHEGVAALR PAPGEEQAGG LRCALLETHE AEVAWVADSI AHLVRTGTAP
GRIAVLCRAG RELFPDVHAA LVARDVPVEV VGLSGLLHLP EIADLVATCE VLQDPTANAA
LVRLLSGPRW RIGPRDLALL GRRARDLVRV AGDDGRQDKL EQAVAEADPT EIVSLADALE
SFLYPGQAGE PELPFSADAA ARFQRLAVEI RELRRALAEP LMDVLHRVLT VTGLEVELAA
SPHALAARRR ETLSAFLDVA AGFADLDGDP SLGAFLAFLR TAQEYDRGLD NNLPSGEDTV
KVLTAHKSKG LEWDVVFVPG LVKGAFPSGT GRERWTSRPE VLPHTLRGDA ASLPADPAWT
SAGLKEFEAE MKTHAATEEL RLGYVAFTRP RALLYASGHW WGPSQKRPRG PSPFLDALRI
FGEEQPGSGV EIEHWAEPPA EDAQNPALDQ TVEHAWPLPL DAAAQAARRA AGTRVLAGSR
GEASPEPEPE AAEERRLVAS WDRDLELLSA ELRRSRSRVR EVALPASLSA SQLLRVAADP
DGFARELARP VPRPPQPAAR RGTRFHAWVE SRLAVEPLLL LGEEELPGLD DSGIEDERDL
ARLKEAFLRT EYAARTPYRI EEPFQLVLGG RVVRGRIDAV YRTPQGFEVV DWKTNHRETA
DPLQLAVYRL AWAEREGLDP ALVSAAFLYV RSGTVVRPQA LPGREGLEAL LDAVAPNGER
IGEAATEAL
//
