ID A0A1H7J3G7_9BURK Unreviewed; 602 AA.
AC A0A1H7J3G7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=H+/Cl-antiporter ClcA {ECO:0000313|EMBL:SEK68437.1};
GN ORFNames=SAMN05192542_103100 {ECO:0000313|EMBL:SEK68437.1};
OS Paraburkholderia caballeronis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Paraburkholderia.
OX NCBI_TaxID=416943 {ECO:0000313|EMBL:SEK68437.1, ECO:0000313|Proteomes:UP000199120};
RN [1] {ECO:0000313|Proteomes:UP000199120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 26416 {ECO:0000313|Proteomes:UP000199120};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FOAJ01000003; SEK68437.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H7J3G7; -.
DR STRING; 416943.SAMN05445871_1795; -.
DR OrthoDB; 9767361at2; -.
DR Proteomes; UP000199120; Unassembled WGS sequence.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR CDD; cd02205; CBS_pair_SF; 1.
DR CDD; cd00400; Voltage_gated_ClC; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR43427; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR PANTHER; PTHR43427:SF6; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 2.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199120};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 447..505
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 514..573
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 602 AA; 63006 MW; BB389313005153E8 CRC64;
MHAAPHKRDF SVNARLPGIC ALAAAIGVLS TAAAYVLLHL IRFFTNLFFF GSLSFADRSP
AGHALGAWVV LVPVAGGLIV GLIARYGSER IRGHGIPEAI EAILFGRSRM SPKVAILKPL
ASGIAIGSGG PFGAEGPIIM TGGALGSLVA QCVRLSAAER KTLLVAGAAA GMTAVFGTPV
AAVLLAVELL LFEWRPRSLI PVALACAVAG FARGAGFGTG VLFPLATAPV MPLSLVSCVI
AGLLCGALAA GLSGALYKVE DLFARLPVHW MWWPAIGGLA VGIGGWIEPR ALGVGYDVIG
DLLHLQLGWQ TAAAILGVKA VIWVIALGSG TSGGVLAPLL MLGAGLGVLT GHLLPGGEPL
LWPLVCMAAT LGATLGAPLT AIVFAFELTH DANALLPLLA ATLVAHALST VVMRRSIMTG
KIARRGRHIY REYGVDPLER HYVDEVMTRD VETIDASLTA QAALAKHFDA TQTHRAYPVV
DEAGAAVGVA DRASLMALAA DERSQHAPLL NSLHVRMPAV ALADETCRLV ATRLAVHGLE
RLPVVADRQS MRLTGIVSRS DLVKLSLAHF DDEHRRERFR RVLPAGGVKR RGRKARRAMA
AR
//
