ID   A0A1H7J8T1_9FIRM        Unreviewed;       454 AA.
AC   A0A1H7J8T1;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Probable multidrug resistance protein NorM {ECO:0000256|ARBA:ARBA00020268};
DE   AltName: Full=Multidrug-efflux transporter {ECO:0000256|ARBA:ARBA00031636};
GN   ORFNames=SAMN04487770_102294 {ECO:0000313|EMBL:SEK70682.1};
OS   Butyrivibrio sp. ob235.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Butyrivibrio.
OX   NCBI_TaxID=1761780 {ECO:0000313|EMBL:SEK70682.1, ECO:0000313|Proteomes:UP000199418};
RN   [1] {ECO:0000313|EMBL:SEK70682.1, ECO:0000313|Proteomes:UP000199418}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OB235 {ECO:0000313|EMBL:SEK70682.1,
RC   ECO:0000313|Proteomes:UP000199418};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000256|ARBA:ARBA00003408}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; FOBE01000002; SEK70682.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H7J8T1; -.
DR   Proteomes; UP000199418; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR   CDD; cd13144; MATE_like_4; 1.
DR   InterPro; IPR002528; MATE_fam.
DR   InterPro; IPR048279; MdtK-like.
DR   NCBIfam; TIGR00797; matE; 1.
DR   PANTHER; PTHR43298:SF2; FMN_FAD EXPORTER YEEO-RELATED; 1.
DR   PANTHER; PTHR43298; MULTIDRUG RESISTANCE PROTEIN NORM-RELATED; 1.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
PE   4: Predicted;
KW   Antiport {ECO:0000256|ARBA:ARBA00022449};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199418};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        21..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        58..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        99..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        129..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        175..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        198..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        263..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        290..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        321..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        362..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        391..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        420..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   454 AA;  49330 MW;  37789028C7B3AACA CRC64;
     MSNSKENKMG VLPVKRLIVS MSLPMMASML VQALYNVVDS IFVAQINENA LTAVTLAFPL
     QNLMIALGAG TGVGMNALLS RSLGEKNFDR ADRAANTTLM LTFINYFVFF MIGIFAVKPF
     LMTQTDNEVI AGYGVSYLSI ICCCSIGVFC QMTFERMLQS TGRTLFSMYS QMSGAIINII
     MDPILIFGMF GAPKMGVAGA ALATVFGQVV GSCIGLYCNL KLNPDVNLRI PLILSPKADI
     VKEIYYVGVP SILMMSIGSL MTYAMNLILI AFSTTATAVF GVYFKLQSFF FMPVFGLNNG
     LIPVLAYNLG AKRKDRINEA LKFSIALAAT IMIIGTITFQ IIPDRLLGLF NASYDMISIG
     KPALRVISLS FPIAGVCIAL GSVFQAFSES IYSLAVSIGR QLVVLIPAAW LLAQTGNVNA
     VWWAFPIAEI ASLILSGFFF KRVYGRRIAE IEEG
//