ID   A0A1H7JSW5_9LACT        Unreviewed;       865 AA.
AC   A0A1H7JSW5;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=Aldehyde-alcohol dehydrogenase {ECO:0000256|PIRNR:PIRNR000111};
GN   ORFNames=SAMN04488099_10628 {ECO:0000313|EMBL:SEK76595.1};
OS   Alkalibacterium pelagium.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
OC   Alkalibacterium.
OX   NCBI_TaxID=426702 {ECO:0000313|EMBL:SEK76595.1, ECO:0000313|Proteomes:UP000199081};
RN   [1] {ECO:0000313|Proteomes:UP000199081}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 19183 {ECO:0000313|Proteomes:UP000199081};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|ARBA:ARBA00001954};
CC   -!- SIMILARITY: In the C-terminal section; belongs to the iron-containing
CC       alcohol dehydrogenase family. {ECO:0000256|ARBA:ARBA00035645,
CC       ECO:0000256|PIRNR:PIRNR000111}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the aldehyde
CC       dehydrogenase family. {ECO:0000256|ARBA:ARBA00035641,
CC       ECO:0000256|PIRNR:PIRNR000111}.
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DR   EMBL; FNZU01000006; SEK76595.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H7JSW5; -.
DR   STRING; 426702.SAMN04488099_10628; -.
DR   OrthoDB; 9815791at2; -.
DR   Proteomes; UP000199081; Unassembled WGS sequence.
DR   GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0006066; P:alcohol metabolic process; IEA:InterPro.
DR   GO; GO:0015976; P:carbon utilization; IEA:InterPro.
DR   CDD; cd08178; AAD_C; 1.
DR   CDD; cd07122; ALDH_F20_ACDH; 1.
DR   Gene3D; 3.40.50.1970; -; 1.
DR   Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR   InterPro; IPR034789; AAD_C.
DR   InterPro; IPR001670; ADH_Fe/GldA.
DR   InterPro; IPR018211; ADH_Fe_CS.
DR   InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR012079; Bifunc_Ald-ADH.
DR   PANTHER; PTHR11496; ALCOHOL DEHYDROGENASE; 1.
DR   PANTHER; PTHR11496:SF83; HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   Pfam; PF00465; Fe-ADH; 1.
DR   PIRSF; PIRSF000111; ALDH_ADH; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
DR   PROSITE; PS00913; ADH_IRON_1; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|PIRNR:PIRNR000111};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199081}.
FT   DOMAIN          15..277
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   DOMAIN          463..850
FT                   /note="Alcohol dehydrogenase iron-type/glycerol
FT                   dehydrogenase GldA"
FT                   /evidence="ECO:0000259|Pfam:PF00465"
SQ   SEQUENCE   865 AA;  95029 MW;  2EB0FD6C721A128F CRC64;
     MVKVLDKTNK VTDVQKDIDQ LVTKAKTALD NMYKLDQEQI DNIVKEMALA ALDQHMPLAK
     LAVEETGRGV YEDKIIKNLF ASEYIYHSIK HDKTIGVINE NLHEGTVEIA EPVGVIAGVT
     PVTNPTSTTI FKSMISIKTG NPIIFAFHPS AQKSSSAAAR AVYEAAVKAG APENCIQWIE
     KPSVEATQTL MKHDGVATIL ATGGSGMVKS AYSSGKPALG VGAGNVPCYI EKTANVKRAT
     NDLILSKTFD NGMICASEQA VIADKEVYEE VKSQMIDNGC HFLTKEERLK VEQLMVSEDN
     HLNPDIVGRS AYQIAKMANV KVPEDTKILI AEYPGVGRDF PLSREKLSPV LAAYKVNSSE
     EGIKRAEEML AYGGLGHSAV IHSNNEQVIS EFDRRMKAGR LIVNAPSSQG AIGDIYNAYL
     PSLTLGCGSF GGNSVSTNVS TMHLINVKKR AKRTNNMQWF KIPPKVYFER NSVQYLAKMP
     DIKKAFIVTD PMMVELGYVD RVLYHLRNRQ EYVHCEIFSD VEPDPSKETV LKGAEAMAAF
     QPDVIIALGG GSPMDAAKGM WLFYEHPDTD FNGIKQKFMD IRKRVYKYPT LGEKAQFVAI
     PTTSGTGSEV TSFSVITDTE KSTKYPLADY ELTPDVAIID PQFVMSVPKV VTADTGMDVL
     THAIEAYVSN MANDYTDGLA IKAIQLVFKH LPTAYHNGDD EVAREKMHNA STIAGMAFAN
     AFLGINHSLA HKLGAQFHIA HGRANAILMP HVVRYNAKKP TKFVAFPKYE HFIADERYAE
     IAKALDLPAS TTEEGVESLI KAIYDLAKEL EIPMGIKDNG VDKKAFEAVV DDMAERAFED
     QCTTANPKMP LVKELAEVYR AAFKG
//