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Database: UniProt
Entry: A0A1H7JUN3_9ACTN
LinkDB: A0A1H7JUN3_9ACTN
Original site: A0A1H7JUN3_9ACTN 
ID   A0A1H7JUN3_9ACTN        Unreviewed;       418 AA.
AC   A0A1H7JUN3;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   10-APR-2019, entry version 10.
DE   RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|HAMAP-Rule:MF_00138};
DE            EC=6.3.4.13 {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=GARS {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Glycinamide ribonucleotide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
GN   Name=purD {ECO:0000256|HAMAP-Rule:MF_00138};
GN   ORFNames=SAMN05414137_103463 {ECO:0000313|EMBL:SEK78242.1};
OS   Streptacidiphilus jiangxiensis.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptacidiphilus.
OX   NCBI_TaxID=235985 {ECO:0000313|EMBL:SEK78242.1, ECO:0000313|Proteomes:UP000183015};
RN   [1] {ECO:0000313|EMBL:SEK78242.1, ECO:0000313|Proteomes:UP000183015}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.1857 {ECO:0000313|EMBL:SEK78242.1,
RC   ECO:0000313|Proteomes:UP000183015};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) +
CC         N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate;
CC         Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58089,
CC         ChEBI:CHEBI:58457, ChEBI:CHEBI:456216; EC=6.3.4.13;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00138};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC       ribose 1-diphosphate: step 2/2. {ECO:0000256|HAMAP-Rule:MF_00138}.
CC   -!- SIMILARITY: Belongs to the GARS family. {ECO:0000256|HAMAP-
CC       Rule:MF_00138}.
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DR   EMBL; FOAZ01000003; SEK78242.1; -; Genomic_DNA.
DR   RefSeq; WP_042453780.1; NZ_FOAZ01000003.1.
DR   STRING; 235985.BBPN01000030_gene2028; -.
DR   OrthoDB; 932854at2; -.
DR   BioCyc; GCF_000787795:G1EJS-2799-MONOMER; -.
DR   UniPathway; UPA00074; UER00125.
DR   Proteomes; UP000183015; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00184; GARS; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Complete proteome {ECO:0000313|Proteomes:UP000183015};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00138, ECO:0000313|EMBL:SEK78242.1};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00138};
KW   Reference proteome {ECO:0000313|Proteomes:UP000183015}.
FT   DOMAIN      107    303       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
SQ   SEQUENCE   418 AA;  42966 MW;  9B83BB3D3107FBFF CRC64;
     MKVLVIGGGA REHALCRALS LDPEVTSLHC APGNAGIAAV ARLHPVDQLD GPAVADLAVE
     LGAEFVIVGP EAPLVAGVAD AVRERGIPVF GPGREAAQLE GSKAFAKDVM AAAGVPTARS
     YVCTTPEEVA EALDAFGAPY VVKDDGLAAG KGVVVTDDLQ AAIDHAAGCD RVVIEEYLDG
     PEVSLFAVTD GTTVVPLQPA QDFKRVGDDD AGPNTGGMGA YSPLPWADPK LVDEVFDTVL
     QPTVDELRRR GTPFSGLLYA GLAITSRGVR VIEFNARFGD PETQVVLARL KTPLNGLLYA
     AATGHLADFP ALRWSEGAAV TVVIASEGYP AAPVSGDPIT GLAEAEAADG TAYVLHAGTR
     LADDGETVLS AGGRVLSVTA TGDNLAEART RAYGAVDRIT LRGSHHRSDI AAKAANAE
//
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