ID A0A1H7K4G9_9FIRM Unreviewed; 511 AA.
AC A0A1H7K4G9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=SAMN02910377_01906 {ECO:0000313|EMBL:SEK81350.1};
OS Pseudobutyrivibrio ruminis.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Pseudobutyrivibrio.
OX NCBI_TaxID=46206 {ECO:0000313|EMBL:SEK81350.1, ECO:0000313|Proteomes:UP000182321};
RN [1] {ECO:0000313|Proteomes:UP000182321}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ACV-9 {ECO:0000313|Proteomes:UP000182321};
RA Varghese N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FNZX01000011; SEK81350.1; -; Genomic_DNA.
DR RefSeq; WP_074791359.1; NZ_FNZX01000011.1.
DR AlphaFoldDB; A0A1H7K4G9; -.
DR Proteomes; UP000182321; Unassembled WGS sequence.
DR GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd11642; SUMT; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006366; CobA/CysG_C.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SEK81350.1};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000182321};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SEK81350.1}.
FT DOMAIN 6..217
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 280..498
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 511 AA; 55994 MW; 1E5F09E617A230AD CRC64;
MSEQKKVVLV GAGPGEWGLL TLKGAEYLKR ADCVIYDRLL NKKFLEMTPD GCEKIFVGKE
NHNHTMKQEN INELLYEKSK EYNLVVRLKG GDSYVFGRGG EEALYLLERG VDVEVVSGVT
SPIAALSAAG IPITHRGLAK GFQVITAHSR KDEAADIDYS QLLEEDVTLV FLMGLSHVGE
IAEGLINAGR SPKTPAAVIS NATTNKQRKC VGTLADISDL VEKANLVSPS IIVVGDVVTL
SDRLSLFEKR PLFGKRYFLP KIIGFNYGFG EKFSYEKTNK LEEQLIQLGA QVYTVDSGKI
VPLEIDLGFL ELTQPSDYIV FTSANGVKAF FYNLYEVCQK DIRSIGPVKI AAIGAKTASA
LESFGVRVDL ISEAQNGKDL ALKISEKIAS GGRVYWLCAS NMSEDFEANL DNRIPLNKIP
VYKNEKLEVS ITDSDLEEIS SYDGAVFTSA SNALFGAEVL GDKMPQQIFA IGNACKRAIS
DRYDNISVAE ISSYEGLLDL IKNYTISTHC I
//