ID   A0A1H7M3N1_9FIRM        Unreviewed;       859 AA.
AC   A0A1H7M3N1;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN   ORFNames=SAMN02910377_02544 {ECO:0000313|EMBL:SEL05856.1};
OS   Pseudobutyrivibrio ruminis.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Pseudobutyrivibrio.
OX   NCBI_TaxID=46206 {ECO:0000313|EMBL:SEL05856.1, ECO:0000313|Proteomes:UP000182321};
RN   [1] {ECO:0000313|Proteomes:UP000182321}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ACV-9 {ECO:0000313|Proteomes:UP000182321};
RA   Varghese N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR   EMBL; FNZX01000020; SEL05856.1; -; Genomic_DNA.
DR   RefSeq; WP_074792256.1; NZ_FNZX01000020.1.
DR   AlphaFoldDB; A0A1H7M3N1; -.
DR   Proteomes; UP000182321; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 1.10.287.130; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   PANTHER; PTHR45528; SENSOR HISTIDINE KINASE CPXA; 1.
DR   PANTHER; PTHR45528:SF14; SENSOR HISTIDINE KINASE CSSS; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:SEL05856.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000182321};
KW   Transferase {ECO:0000313|EMBL:SEL05856.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT   TRANSMEM        12..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        388..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        433..453
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        465..490
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        534..553
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          642..840
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
FT   REGION          227..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   859 AA;  98057 MW;  EA78BDA1953718C2 CRC64;
     MKRLYSNASK ILLAVGCTIF AFICVLSLVI CAFFQSWKLY SNDKEAFSDF AYRYAGTSYA
     TLALSDNQDD FNEDKLDKMN CYYGIINGTN AENIDLDDES LYLYKNFTTT VPDNAYVGDY
     SINPDTEFVL SDNFLDIWGG NQIIDVNTTE WKTYDINGIG YDPISQNMYV YSNGEFYKLS
     ELCYDICTVT YADEESKEDA YWNSSANIIY RKIWEANKPD AVDYYTPLEE GDSDETTYTI
     EDEDSDESTE EETTDETTEE YEVDYLPAER ALPNAPVENT DGLYIEDTQF SPITDSIDDF
     AINIYVDGYG EEAPMGEYIA DFSTIHNTLS EINYEAYLET ASTVEVATLN PETENYVFVC
     FPKDTFNGVN DFYAQAKWFI GFAEDTKYVF PIAAVLSFIL SILCYVLFMC AIGHKKNSAE
     ISVNWIGKVW TDVFFWCAII TEYIIFAIFY WLVETMRDSN LSLGMSIFIF GIVTAAMMAV
     GLMWSANLAV NVKLHRFFKH TFAYRLFVWS KGRLAILHQQ SIKIRKNIKW TRRIWFIFIV
     ITIIEYFVIM MSYDTRGIAP FWVLEKIAFV VVLRKLLYSY ARIKETATAL AAGDLSAKVD
     LNGMPLFLAE HAVAMNQIGD GINVALDERT KSERMKTELI TNVSHDIKTP LTSIINYVDL
     LNKEKIDNEK AKEYLGVLSR QSARLKKLIE DLIEASKAST GNIKFTMEKI NAVVLLNQSI
     GEFSERLEAG KITVVTDFPA EDIFLKADNR YLWRVFDNLM SNIVKYAQPD TRAYIDLKRV
     DGKVRFNFRN TSKNELNISA DELMERFVRG DKSRFTDGNG LGLSIAKSLT ESMGGSLTLE
     IDGDLFKAIV EFDELKTEE
//