ID   A0A1H7MD19_9BURK        Unreviewed;       693 AA.
AC   A0A1H7MD19;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SEL08981.1};
GN   ORFNames=SAMN05216319_1000 {ECO:0000313|EMBL:SEL08981.1};
OS   Duganella sp. CF402.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Oxalobacteraceae; Telluria group; Duganella.
OX   NCBI_TaxID=1855289 {ECO:0000313|EMBL:SEL08981.1, ECO:0000313|Proteomes:UP000198529};
RN   [1] {ECO:0000313|Proteomes:UP000198529}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CF402 {ECO:0000313|Proteomes:UP000198529};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
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DR   EMBL; FOBG01000001; SEL08981.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H7MD19; -.
DR   STRING; 1855289.SAMN05216319_1000; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000198529; Unassembled WGS sequence.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-KW.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR   PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Peroxisome {ECO:0000256|ARBA:ARBA00023140}.
FT   DOMAIN          295..470
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          475..567
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          603..690
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   693 AA;  74673 MW;  BD7F6DC68040E1A6 CRC64;
     MTAEYQVHGA VAVITLNNPP VNGMGLVTRT AAVKGIQQAL ADDAVKAIVI TGAGKAFSGG
     ADIKEFNTPA ALAEPSLHTF IATAESSTKP VVAAIHTVCM GGGLELSLGC HYRVALPGAQ
     IALPEVKLGL LPGAGGTQRL PRVLGLEPAL NMIVSGNPVP SEKLPALFDQ IFAADADIVQ
     SAVAFAEKIA DVRPLPKVRD RKVDYPNHEA FLQFSRNTVK AMSGPFPAPL ECVETVAASV
     TMKFEDGMKF ERERFLHLIQ TTESKSLRHA FFSERTASKV PDVPADTPVR SIKSAAVIGA
     GMMGGGIAMN FLNAGIPVKL LETRQEALDK GIATIRKNYE SSLKKGKLTQ EKLDQRMGLL
     TSTLSYDDIG QADIVVEAVF EEMGVKEAVF RKLDEVMKPG AILATNTSTL DVDKIAAFTK
     RPQDVIGTHF FSPANVMKLL EIVRGKQTGK DVLATALALS KKLKKTGVVS GVCDGFIGNR
     MIEQYSRQAG FLLEEGALPE QVDKAAEKFG FAMGPFRMGD LAGNDIGWAI RKRRYVEKPE
     ITYSKTADLL CEMGRYGQKT GGGWYDYKAG DRKAYPNEQV NAMIVQHSAD LGITRRKISD
     EEIVERLVYS LVNEGALILE EGIALRASDI DMVYLTGYGF PLYRGGPMFY ADTVGLPNVL
     AAINKYAKGH QGQAWKPAPL LLKLAAEGKL LNS
//