ID A0A1H7ME56_9GAMM Unreviewed; 2153 AA.
AC A0A1H7ME56;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:SEL09198.1};
GN ORFNames=SAMN05428989_1410 {ECO:0000313|EMBL:SEL09198.1};
OS Pseudoxanthomonas sp. GM95.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Pseudoxanthomonas.
OX NCBI_TaxID=1881043 {ECO:0000313|EMBL:SEL09198.1, ECO:0000313|Proteomes:UP000199164};
RN [1] {ECO:0000313|Proteomes:UP000199164}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GM95 {ECO:0000313|Proteomes:UP000199164};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
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DR EMBL; FOAX01000001; SEL09198.1; -; Genomic_DNA.
DR STRING; 1881043.SAMN05428989_1410; -.
DR Proteomes; UP000199164; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd12116; A_NRPS_Ta1_like; 2.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 988..1062
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2050..2127
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2153 AA; 233997 MW; C8547ADF84D1E863 CRC64;
MKPDALAPAA LTAVDYDPFA SVALARVVPS TEAQREIWLA SQLGVEASLA FNESVSLRLR
GTLDRNALHA ALGELIARHD ALRASFGPDG ETLCVSAQSE LPLPLIDLQD LDEAARADAL
AERRRATVET AFELEQGPLM RAELLCLGSN EHVLLLTAHH IVCDGWSWWV MVRELSTLYG
ARTGLAAGTL PPVASFADYA LDLARHGDDG TLAADQAWWL AQYVQLPAPL DLPTDHARPP
RRSFASARID HVLDAALVGE VKRLGAQRGA SLFATLLGSF AAVLARLSGQ QEVVVGIPAA
AQSLDGQDHL VGHCVNLLPL RCVTDPAAPL AHLLEATQAT LLDALDHQRY TFGTLLRKLD
VPRDPSRLPL VSVLFNIDQA LDQQVTAFPG LVLDFASNPR SFENFELFIN AVQEQGHLRL
ECQYSRELFD GSTVTRWLEA FETLLRGAVA RPDALLGALP IVGEAGRRHL LSLQPAATPI
PTQSIHALFE AQCRRTPDRI AVRCDGQAMT YAALDARANR IAHLLRRNGA RDDALVGIAL
DRSVDLLAAV LGALKTGAGY VPLDPGFPTE RLSYMVGDAS LAVLLTQTAH ADRFDLRGRP
VLALDQLGEE LAALPAEALD EAGDSGDAVA YVIYTSGSTG QPKGVAIPHT AVVNFLTSMA
QRPGLRADDR LVAVTTLSFD IAVLELLGPL GVGAEVVIAR RENALDGEQL KQLLVAAQAT
VMQATPATWR MLLETSWSPP KAFRALCGGE ALAPDLAEAL LDRCGEVWNL YGPTETTVWS
TCWRVERPGE GISIGTPIAN TMVWILDEQR QLCPLGVPGE IWIGGAGVAL GYRNRPELTA
DRFVADPFAS QPDARLYRTG DRGRWRVDGM LMHLGRLDFQ VKLRGFRIEL GEIEARLLSL
PGVADAVAST REFRPGDVRL LAHLVAAQRS VIDEAAVRAH MHQTLPDYMI PQHLIVLDAL
PRLPNGKINR ARLRAPSERP GADEARTLPR DATEERVVAA MAAVLGHAPG VDDNFFEHGG
HSLLAAQLVA RLNRELGLAL PMRMVFEAQT AARLAAVVRA AGTTGATSAA DNGLRITHQS
DRTRAPLSLM QQRLWYLEQL HPGRVVYNTP SAHRLRGPMD EAAFERALQE VVDRQAILRT
SIEAEDGVPE QRIHEAMPVR LLPVETLTGD SLAEREAALM ARLDALIAEP FELASEPLFR
ARLFRLGEND HVFFFMAHHI IWDGWSFDVL YTELSAAYAA FCAGQPMPLP PPAIDYGDFA
GWQREWMQGE ELERQVSHWC ERLANLPEPL ELPAARMRPP RPSGAGATEW IRLPAAQMEA
VRALGQRTGA TAFMVLLAAY YVFLHRNGGQ RDLVVGVPVR GRERAELEAV MGFFVNALPM
RVKIDPQASF LETVQQVRDV VLDSFAYPDV PFEHLVRRLR LPRDERRSPI YQASFSFQDV
RHRNLSWAEL QHEHLPVFQQ GAAEDIGLWF IEQEHGLLGG LTYSTDLFDA EAAARLRNYY
ETLLDSALAD PALPVSLLAF LPAAEIAQLE AWNATAAPIP GERLHGLFEA QATRTPERIA
VRDANGALTY AELDALANRI AHALHACGVR SGALVGIALE RGTGMVAALL GALKAGAGYV
PLDPAFPAER LAFMIQDAGL AALVSDASSL SRLPRIDHPV LRLDAPGALD DLPATSLQTR
VDPDAIAYVI YTSGSTGQPK GVEIPHEAAV NFLTSMAERP GLRAEDTLLA VTTLSFDIAV
LELFGPLSVG GEVVLARRED AMDGETLKEL LATHRCTVMQ ATPATWQVLL QAGWVAAPRF
RALCGGEALT PELAAQLLVS CSEVWNLYGP TETTVWSTCW RVQDAQQGIS IGTPIANTTV
WILDEQGQRC PVGVSGEIWI GGAGVACGYH NRPELSAERF VPDPFASQPE ARLYRTGDRG
RWCADGTLEH QGRLDFQVKL RGFRIELGEI ESIARQEPGV AECVAAVHEV DPLDRRLVLY
VVASEAEDAV LPRVRAKLAE QLPSYMQPQH LVTLPALPRL PNGKTNRKAL PAPPLHAGST
GDADEAAWLA NADPRQRYLS ALWCELIGVG QVQPNDNFFD TGGHSLLAME LAARVRRETG
MRINLLDIAT GTLASLAAGL PEGDGTASAE EPEAPVTLGG RLRRWAGLEP RAR
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