ID   A0A1H7MRR9_STIAU        Unreviewed;      4469 AA.
AC   A0A1H7MRR9;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:SEL13962.1};
GN   ORFNames=SAMN05444354_10488 {ECO:0000313|EMBL:SEL13962.1};
OS   Stigmatella aurantiaca.
OC   Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC   Archangiaceae; Stigmatella.
OX   NCBI_TaxID=41 {ECO:0000313|EMBL:SEL13962.1, ECO:0000313|Proteomes:UP000182719};
RN   [1] {ECO:0000313|Proteomes:UP000182719}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17044 {ECO:0000313|Proteomes:UP000182719};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; FOAP01000004; SEL13962.1; -; Genomic_DNA.
DR   RefSeq; WP_075006156.1; NZ_FOAP01000004.1.
DR   OrthoDB; 5349841at2; -.
DR   Proteomes; UP000182719; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 3.
DR   CDD; cd19543; DCL_NRPS; 1.
DR   CDD; cd19531; LCL_NRPS-like; 3.
DR   Gene3D; 3.30.300.30; -; 4.
DR   Gene3D; 3.40.50.980; -; 6.
DR   Gene3D; 1.10.1200.10; ACP-like; 4.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 4.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR020802; PKS_thioesterase.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 4.
DR   Pfam; PF13193; AMP-binding_C; 4.
DR   Pfam; PF00668; Condensation; 4.
DR   Pfam; PF00550; PP-binding; 4.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00823; PKS_PP; 3.
DR   SMART; SM00824; PKS_TE; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR   SUPFAM; SSF47336; ACP-like; 4.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 8.
DR   PROSITE; PS00455; AMP_BINDING; 2.
DR   PROSITE; PS50075; CARRIER; 4.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000182719}.
FT   DOMAIN          964..1039
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2003..2078
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          3051..3126
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          4095..4170
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          1975..2003
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   4469 AA;  487792 MW;  CC3828D0A25283AF CRC64;
     MTEAELIEDI YELAPMQHGM LFHSLLEPSE GMYVEQLSCE VRGKLPLERW KAAWQHVLGR
     HAILRSSFLW EGLEKPVQVV AVEAELPWHI EDLRSASGEE QDRRIESFLR EDRLRGFDLA
     SPPLLRCALL RLGEERYRFV WTYHHLLLDG WCFSIVLSEV LESFAGGLEA LPPPARPYRD
     YITWLQEQDP TRAESFWRDM LRGFEQPTPL PFMERRQAGK SDSGAQPEVV RHLPRELTAR
     LVTFAKEHRL TLNTLVQGAW GLVLGRTTGT DDVIFGVTVS GRPSDLAGSE SIVGLFINTV
     PLRARLEDTA TVPAFLSALQ VQQSSFEPHG YVSLADIQLW SDAPHDRPLF ESLLVFENYP
     IDRSTLLERS GLEISSIHAH ERINYPLAVV AIPGESLELR VMYQEDTFSR AAAERIGRLL
     EVALGTLTTA KTIGEINFLD EAARRVLAEW GQNPRTFDFR APVHELIARV ARDTPGALAL
     VGADGQKLSY RELDERADRV ARGLRLLGAG RETIVGVCIS RSVELVVGLL GVLKAGAAYM
     PLDPNYPRER LTYLVGDASP AAILNTGADP VPDTRLPRID ISRASLDAGA LDAPAREASH
     LEDLAYVIYT SGSTGAPKGV LVSHRNLLNL VSWHTEAFGL TAKDRTTQLA SVAFDAAVWE
     IWPTLTVGAT LHLVPPELPA APAELSRWLV ERQITISFLP TAVAEAALLL PWPGNCALRF
     MLTGGDRLHV VPPPDLPFRL VNNYGPTETT VVATSGTVGT ESRNGLPSIG RPIANARIYI
     LDRMRRPVLP GVIGELYIGG AGVTRGYLNR PELSAGRFFP DPFSEVPTAR MYASGDLARF
     LPDGTLAFHG RVDRQLQVRG VRIEPGEIEA TLAEYPGISA AAVVGEDVLG NGDIRLVAFT
     VCASQSPPDA AALASYLGKK LPEVMIPKQI ISLSELPLTP NGKVDYAALQ ARAKQEQVHT
     EHIAPRTPHE EILAGIWSAV LGLERIGVEE DFFALGGHSL KATQVIARAR EAFGIDLPVR
     TIFERRTIAL LAEAVAGQGG STEPIPRLEL SGDGPLSPGQ ESLWFIDALG GNTEAYNVPL
     VIQLNGTLDS AAVTRSLALL VERHEALRTT FHERGGTPVQ RIGPPPSSVL SYEDITPELL
     DQRISEEITT PFSLTTGPLF RARLFRLAPD THTLVINQHH IIVDAWSLGV LLREFCIAYA
     AFVSGERPEL PELPNRYTDW VAWQQQRLGA GRTEEGLAYW RQALRGAPQV LTLPSDRPRP
     TRQSFRGKTL SFALEGSIGR SLEALSRGSG ASLFMTLLSA FAAYLGRLSG QDEVVIGSPT
     ANRDRRETEN VVGYFLNTIA LRIDLSGDPS FTELLQRVRK AALDGYTYQD IPFEKVVAAL
     ELPRALSHNP LFQVMFSLQG QSGGEIQLPG VRVTLPTPES PTSKFDLTLF VEPREDAFAC
     LLEYNTDIFD EDRIRRMATH LVRVLEAVAE DPELRISEVP LLSPEERQLI AQLGQPGRPD
     GSRTLLELFE RQVEKTPEAT AIEHRGEVRT YRQLNQEAGA LADRLAVLGA GPDVRVAICL
     ERSITAPISV LAVLKAGATC VPLDSTESPE RLQSVLEDAK ACVLITEKKY RGLSLPHGTE
     VIWVDDSAAP AVKASRPRME PHHLACVLYA SGSGGEPKGV AMPHRALLNL ATWHLAQSRP
     LRTLQYALLN TGASLQEFFS TWCSGGTLVL AGDANRLAPH ALVQLLEEAH IQRLFLPAGA
     LHPLAREAVN APRPVPGLEE IIAAGEQLRI TEPIRQWFAA SKKRLRSQYT VAEAFVAAEH
     ELTGSPESWP GLPPLGRPIP NTAVHLLDTH HRPVPVGVPG EIYVSGACLA EGYLSRPELT
     AERFLELSID PPVRAFLTGD LGRLCWDGTV EFCGRADGQI LVRGIHVEPG EVERVLCAHP
     SILDAVVVAA GDPSREQRLV AYLTPETARI EELPAFLAAR IPEYMVPSQF VALPELPRTP
     GGKRDRRALP VPGQTGRGEA ATGPRTPMEA LVAQAFEQVL GRSPVGLHED FFQLGGNPHL
     ALQAVARISA AVNAEVRVAD LLKNPAVAPL SRALNERQGS RTALPSAIEP APESARAALS
     FSQERLWFLD QLYPGTAVHN LSMALRLKGA LDTGALMESL AGLIQRHPVL GMRFVERDGR
     VWQEPRVKGE VPCELSVPGP LSATELRRLL HEEAVRSFDL ANGPLFRARL FRIDDSEHIL
     VTTMHQAVSD HASLRVFVRE FSQLYAAHVS GRSAQLPALP MDFLSYAREQ RHSLQGEALE
     ERLGYWRQNL HGAPGALGLP ADRVRPPQPG FRGATQRLAL SRGLSEGLKT LSHRLEVAGL
     EVLLSGFAAY LARITGQEDI VIGLPVAHRD RAELKPLIGR FEGALPIRID LSSNPTFEEL
     VARVHRATLG AYAHQDVPLE KIVEAVDAER DLSQTPLFQV MLSLQDASEG SVALPGLNVE
     PLSLELGTAK FDLALIFEPV VGELTGMIEY GTDLFDPDRI ERMAGHLLTV FEDAMAYPGK
     RISELLLLPE EERRTVSAFA KGRVLPPARE VPVHKLVEEH ARRAPDSIAL ELGGAVLTYG
     ELNERANRAA HQLMDMGAGP EKLVALAVPR SFELLIGLLA IWKAGAAYVP LDLSYPKARL
     DTIFEDSGAR LLVSTRTAES RWRVPHVSTL WLDEPSNSEL SGNPDSGVRM ENAAYVIYTS
     GSTGQPKGVI LEHRGLANVI EMQRHELGAD SNCVMLQFSS ISFDVSVWEI VMALTNGGRL
     VLAPADTLLA GEELAKVLIT HRVTHMVLPP TSYAVLPADR EYPSLRLLLA AGEALPPEVV
     NTWAKPGVQF VNAYGPTEVT IICTLGQCKQ GEPSAPPIGR PALNLEGYVF DSHGALLPIG
     VPGELYLGGV GVARGYLNRE GLTREKFIPH PFEPGARLYR SGDLVRWRKD GNLEYLGRID
     HQVKLRGYRI ELGEIEAVLA THPGVAKAVT IVHSAGNSGG VKLLVAYVVP AGPVDAHSIR
     DHARKRLPEF MVPAEIILLE ELPLTSSGKV DKKRLPSPRL EEHEARASFV APHTPTEKTL
     AALWEELLEK RPIGTGDNFF QLGGHSLLAA QVMSRVRRTL GVEVPLSAIF EQPTLGALAS
     VIAAKEAAPQ LPPLVRLKGE GDRPLSFSQE RLRFLAELEG DSAAYNIPIA FSLRGPLHEG
     ALSRSLARVV DRHQPLRTCF PLVEGQPVAR LIEGGIPLVT EDLRRSGAPT LDRRLKEESS
     RPFSLDRGPV VRAHLFKAAE QEHVLLVVMH HIVSDGWSFG IMMRELSEIY AAEVRGEKRE
     LPELPIQYAD YAAWQRSWLE GHVRDQQLAY WRSALAGAPA VLELPADRPR PIVRSHRGAV
     ESLELDRGVA QALTALCRQE GVTSYMALLA AFGAWLGRVS GQDDVVIGSP FAGRRIAETE
     PLIGFFVNTL PLRVDLGGDP SFLELLQRVR RQVLAAHENQ DVPFEKLVEK LNPERVLGTS
     PLFQVMLAFQ PAQPDGMELP GLEVKPVPMP TGTAKFDLTL SLEETGQGVR GWLEYDLDLF
     DAWRVQAMVR QLTCFITGLT TAPKARISEA ELLSAEERVK LIPSAPEEMP RLPAVHEVIA
     AQAKKTPAAI AVEAEDGTLR YDELEARAGA IAHELVRRGV TPGTLVAIAV ERSLGMMAGL
     LGILKAGAAY VPLDPAYPRE RLAFMLKDSG ARVVITQEHL APMFPEAEVL VLDAARKGSS
     EPRSGALAYC LFTSGSTGQP KGVLIEHSSL ANHMEWMNEA LPLGPEDRVL QRTSLSFDAS
     VWELFAPLMA GARLVLAPHG LGADTEHLVR VLRERGITVL QLVPSLLTAL VEEPGLAGVS
     TLRRVCVGGE PLPSATVKKL FSVCNVEVWN LYGPTEATID AIAHRCRPEE VGAHGATEPI
     GLPIRRMKAL ILDGRLRPVP DGLPGELYLS GPGLARGYLN RPELTDSRFI EHSFPGGPRL
     RMYRTGDVVR RQADGTILFT GRADRQVKLR GYRIELGEVE AALARHPAVR EAVALVSGTS
     GDARLVAFVV PKAGAKQPEA SELRGFVEQQ LAAHMVPGQF VLLAELPHAP NGKVDFRALG
     TMELAEERVT SSGGIPRDAM ELELVRLFEE ILGARSVGIH DSFFELGGHS LLALKLKLAV
     EKRLKRPLPL VSLFRNPAPA QLAELLRSGT SAVSPLVPLT PSARALLASE PVGSGARRPP
     TLFLVPGGGS TPFYLLSLAR HLEGYAVFGL QPRGLDGEAP PFEKLEDMAA WYADAILSVQ
     PEGPYFVGGH SMGGQIAYEI AQQLQARGHE IGVVALLDAL APHPEATRPM GEGWDTSQWL
     IHLAGVMEAF FNVKIGLGLS EVRAMGDAER LDAFVVRLQS AGVLPAGAQP GHVMGILNVT
     RALDAMNYQP RRRQPVPLAV FRAEDRDGPT SPELDALFAD DTLGWDRLTQ GSSTAYRVPG
     SHLTLIREPH VGILARHLLT LLTGRTRDL
//