ID A0A1H7N7C8_9BURK Unreviewed; 889 AA.
AC A0A1H7N7C8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SAMN05192542_105365 {ECO:0000313|EMBL:SEL19516.1};
OS Paraburkholderia caballeronis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Paraburkholderia.
OX NCBI_TaxID=416943 {ECO:0000313|EMBL:SEL19516.1, ECO:0000313|Proteomes:UP000199120};
RN [1] {ECO:0000313|Proteomes:UP000199120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 26416 {ECO:0000313|Proteomes:UP000199120};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; FOAJ01000005; SEL19516.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H7N7C8; -.
DR STRING; 416943.SAMN05445871_1591; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000199120; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000199120}.
FT DOMAIN 706..722
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 632..639
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 889 AA; 96111 MW; F7EB152A3BF00E79 CRC64;
MATHTAGAGD IAQHTPMMQQ YLRIKADHPG TLVFYRMGDF YELFFDDAEK AARLLDLTLT
QRGASAGNPI RMAGVPHHAV EQYLAKLVKL GESVAICEQI GDPATSKGPV ERKVVRVVTP
GTLTDAALLS DKNDVYLMAV CPGHNRRGVA VNVGLAWLNL ASGGLRLAEV APGQVAAAFE
RIRPAEILVA EMPAESAGWT PPTGFGALTR VPAWHFDVTS GTQRLRDQLD VASLDGFGAQ
TLTSACGAAG ALLLYAAATQ GQQLRHVRSL KVEYESEYIG LDPATRRNLE LTETLRGTDS
PTLCSLLDTC STTMGSRLLR HWLHHPPRDA SIAQTRQQAI GALLEAPPPA NLDALRSALR
QIADVERITG RLALLSARPR DLSSLRDTFV ALPTLRDQVA VASGAAASLA RIGDALEPPA
ACVELLQRAV APEPAAMVRD GGVIARGYDA ELDELRDMSE NCGQFLLDLE TRERTRTGIG
NLRVEFNKVH GFYIEVTRGQ TDKVPDDYRR RQTLKNAERY ITPELKAFED KALSAQERAL
SRERALYDAL LQSLLPFIPD CQRVATALAE LDLLAAFAER ARALDWNAPT FSDTAGIEIE
QGRHPVVEAQ VEQFIANDCV LNGDRKLLLI TGPNMGGKST FMRQTALIAL LAYVGSYVPA
KHARFGPIDR IFTRIGAADD LAGGRSTFMV EMTEAAAILN DATPQSLVLM DEIGRGTSTF
DGLALAWAIA RHLLASNGCH TLFATHYFEL TQLPAEFPQA ANVHLSAVEH GHGIVFLHAV
DEGPANQSYG LQVAQLAGVP GAVIRAARKH LVYLEQQSAG QPAPQLDLFA APADAPTIVE
DAPEPQADPV AAAVAERLRA LDPNELRPRE ALDLLYELHE LATARNAKH
//
