ID   A0A1H7R036_9BURK        Unreviewed;      1036 AA.
AC   A0A1H7R036;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Multidrug efflux pump {ECO:0000313|EMBL:SEL53512.1};
GN   ORFNames=SAMN05216319_2035 {ECO:0000313|EMBL:SEL53512.1};
OS   Duganella sp. CF402.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Oxalobacteraceae; Telluria group; Duganella.
OX   NCBI_TaxID=1855289 {ECO:0000313|EMBL:SEL53512.1, ECO:0000313|Proteomes:UP000198529};
RN   [1] {ECO:0000313|Proteomes:UP000198529}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CF402 {ECO:0000313|Proteomes:UP000198529};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FOBG01000001; SEL53512.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H7R036; -.
DR   STRING; 1855289.SAMN05216319_2035; -.
DR   Proteomes; UP000198529; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF21; MULTIDRUG RESISTANCE PROTEIN MDTB; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        340..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        364..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        435..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        467..486
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        533..552
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        861..879
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        899..925
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        962..980
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        992..1016
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1036 AA;  109948 MW;  696D99A922900209 CRC64;
     MSPSAPFIQR PVATSLLMLA IVLAGIVGFK FLPLSALPQV DFPTIQVQTL YPGGSPEVMA
     QTVTAPLERQ FGAMAGLSRM SSTSAAGVSI ITLQFGLGQS LDVAEQEVQA AINAGNSLLP
     TDLPAPPVYA KVNPADAPVL TLAITSDTMP LTEVQNIVNT RLALKISQVS GVGLVTLSGG
     QRPAVRIQAD TNALASYGLG LDTLRTAITA ANANGAKGSF DGPTRAYSIN ANDQLVTAKD
     YKELILTYKN GAPVRLTDVA QVVDSAENVE LGAWAGTSAG TRQAIILNVQ RQPGANVIAT
     VDGIKARLPE LQAGLPGAMH VEVLSDRTTG IRASVEHVEF ELLLAVVLVV LVIFAFLHSL
     RATIIASLSV PISLIGTCGV MYLLGYSLNN LSLMALTIAT GFVVDDAIVM IENIARYIEE
     GETPMAAALK GAKQIGFTII SLTVSLIAVL IPLLFMGDVV GRLFREFAIS LAITILISAV
     VSLTLVPMMS ARWLKNHADE KPTRFAQRFQ QFFDWVIHHY DTSLTWVIKH SGLTLLVALG
     TLVLTAVLYI VIPKGLFPTQ DTGQLQARLE TGKAVSYVKM ADLQQQAAKV ILEDPDVNNL
     SSVVGVDAAN NTMLHTGSML INLKHQRTSS QQETMDRLRA RVAEIPGLTL YLQPTQDLTI
     DAETGPTQFR VSIEGADNAT VNEWATKLAA QMRTKSQVRN VVSDVGASAN AAYVSVDRDT
     ASRLSVTAAA IDDALYSAFG QRIVSTIFTE TNQYRVILEA RRDDVSTPAD LGNLQLKTGS
     GKATPLSAVA TVTERPAPLQ ITHVAQYPAT TLGFDTAPGV SLGTAVDSIR TAAAEIKMPA
     SVTMTFLGAA GAYQNSLSNQ LWLILAAVIC VYIVLGVLYE SYIHPLTILS TLPSAGVGAL
     LALLVTGQGL GVIGIIGIIL LIGIVKKNAI MMIDFAIEAE RDEGKPPREA IHQAALLRFR
     PILMTTLAAL FAAVPLMLGF GEGAELRRPL GLAIFGGLIV SQMLTLYTTP VIYLGFDSLA
     RRLRGKPEAQ VEGGAL
//