ID A0A1H7SRF3_9GAMM Unreviewed; 819 AA.
AC A0A1H7SRF3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN ORFNames=SAMN05216262_12038 {ECO:0000313|EMBL:SEL75200.1};
OS Colwellia chukchiensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Colwelliaceae; Colwellia.
OX NCBI_TaxID=641665 {ECO:0000313|EMBL:SEL75200.1, ECO:0000313|Proteomes:UP000199297};
RN [1] {ECO:0000313|Proteomes:UP000199297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.9127 {ECO:0000313|Proteomes:UP000199297};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR EMBL; FOBI01000020; SEL75200.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H7SRF3; -.
DR STRING; 641665.GCA_002104455_01548; -.
DR OrthoDB; 5807460at2; -.
DR Proteomes; UP000199297; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd05784; DNA_polB_II_exo; 1.
DR CDD; cd05537; POLBc_Pol_II; 1.
DR Gene3D; 2.40.50.590; -; 1.
DR Gene3D; 3.30.70.2250; -; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Reference proteome {ECO:0000313|Proteomes:UP000199297};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442}.
FT DOMAIN 91..330
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 411..791
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 819 AA; 92913 MW; 979227CC826B0031 CRC64;
MQFSPEKVTT HAAPLIANRG FLLTRSARDR NDRLEISLWL KTPQGPAQLL INNERAVFFV
EQTSLAHAKS VLAQQQVNLD EIKALPLKTF KQRPVFALYF LSLREFYQAR AALHKQGIKC
YEDDIRPDDR YLMERFITAD ITFAGQQAWL TPKFAGTFTR FEHVKCKRLD KSQQTDIKLS
TVSLDIECAM SGELYSVGLY SENCQQVLMI ASATDIAREQ QANPDADIDI VWQADEKQLL
LSLLAWFQAH DPDIIIGWNV INFDFSLLQK RFDLYGLTFA IGRDAQAPYW RKNKASEQQF
IDINGRVVLD GIDLLKTATY NFPSFSLDNV ANTLLGLGKK VTDVDNRIAE INHNFHHDKT
ALARYNLEDC RLVLLIFQHT QLLEFAMLRA QLTGLAIDRI GGSVAAFTNL YLPKLHRSGY
VAPNMGDGEQ GFESPGGFVM DSIPGLYKNV LVLDFKSLYP SIIRSFNIDP MGLIEGLKSP
DTAIAGYDGA LFSRTAHFLP AIITALWQER DKAKVENNAA LSQAIKIIMN SFYGILGSAG
CRFFDPRLSG SITKRSHSIL KTTKVWIEAK GYRVIYGDTD SIFVHIGDQH NGASSRALGK
VLQDDINHKW QQLLKTDYGI ESALEIEFET RFSKFLMPTI RGQDIGTKKR YAGLVEKGGE
QQLIFKGLES VRTDWTELAK QFQRTLYLKI FNDEPVADYI KAVVADTLAG KHDQLLYYRK
RLRRKLSDYV KNVPPHVRAA RLADEIYQQQ GKPQRYQNKG WIEYVMTTNG PQAKGCQSAA
LDYQFYIDRQ LMAVADAILP FINSSFDEIT NSQMTLFDR
//
