ID A0A1H7T3I4_9RHOB Unreviewed; 621 AA.
AC A0A1H7T3I4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase {ECO:0000313|EMBL:SEL79278.1};
GN ORFNames=SAMN04488526_3545 {ECO:0000313|EMBL:SEL79278.1};
OS Jannaschia helgolandensis.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Jannaschia.
OX NCBI_TaxID=188906 {ECO:0000313|EMBL:SEL79278.1, ECO:0000313|Proteomes:UP000199283};
RN [1] {ECO:0000313|EMBL:SEL79278.1, ECO:0000313|Proteomes:UP000199283}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14858 {ECO:0000313|EMBL:SEL79278.1,
RC ECO:0000313|Proteomes:UP000199283};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR EMBL; FNZQ01000010; SEL79278.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H7T3I4; -.
DR STRING; 188906.SAMN04488526_3545; -.
DR OrthoDB; 3194735at2; -.
DR Proteomes; UP000199283; Unassembled WGS sequence.
DR GO; GO:0016823; F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR030817; Myo_inos_IolD.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR NCBIfam; TIGR04377; myo_inos_iolD; 1.
DR PANTHER; PTHR18968:SF9; 3D-(3,5_4)-TRIHYDROXYCYCLOHEXANE-1,2-DIONE HYDROLASE; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:SEL79278.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199283};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 8..132
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 220..352
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 429..571
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 621 AA; 66813 MW; 8907899171C578B1 CRC64;
MTDTIRLTVA QAIVRWLLAQ HIDIDGTRTR ICGGGFGIFG HGNVPCLGEA LYPVRDQLPL
YRGQNETSMG FAAAGYAKYH LRRRFMFCTA SAGPGTANLL TAAALAHANR LPMLMLCGDT
FLTRLPDPVL QQLEHFGNPA LGVNDAFKAV TRFWDRITHP AQILQSLPAA LATMLDPADC
GPAFLGLPQD VQGWAWDYPK AFFDNRTHRI RRQMPDTVEI SEAATILKSA ERPVIIAGGG
VQYSGAVAEL TRFAETHDIP VIETIAGRAN LLDDHPLNIG PVGVTGSNSA NWTAENADVI
FAVGTRLQDF TTGSWTAFAR NARLLTLNVG RHDAAKHLAT TVVGDAKLGL NAVGDALGNH
KTPADWTAKA KAERAKWNDY RAENVTPGNR PNSYAQAIGT INALMAPSDR VVAAAGGLPA
EVTANWRTLK AGTVDVEFGF SCMGYEIAGG WGARIAQAED EPDSDTVVLT GDGSYLMLNS
DLYSAVLTEK KLIVLVLDNG GFAVINKLQN NTGQDSFNNL IADTPTATRQ VRVDFESHAK
AMGAHAETVS NAGELADAFT RAKASALTTV IVMQVDPYDG WTSEGHAWWE IGTPEISETR
SVTAAHKDVE ATRTKRQRKG I
//
