ID A0A1H7TMP8_STIAU Unreviewed; 282 AA.
AC A0A1H7TMP8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Aldo/keto reductase {ECO:0000313|EMBL:SEL85127.1};
GN ORFNames=SAMN05444354_10946 {ECO:0000313|EMBL:SEL85127.1};
OS Stigmatella aurantiaca.
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Archangiaceae; Stigmatella.
OX NCBI_TaxID=41 {ECO:0000313|EMBL:SEL85127.1, ECO:0000313|Proteomes:UP000182719};
RN [1] {ECO:0000313|Proteomes:UP000182719}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17044 {ECO:0000313|Proteomes:UP000182719};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FOAP01000009; SEL85127.1; -; Genomic_DNA.
DR RefSeq; WP_075007743.1; NZ_FOAP01000009.1.
DR AlphaFoldDB; A0A1H7TMP8; -.
DR OrthoDB; 5523216at2; -.
DR Proteomes; UP000182719; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43638; OXIDOREDUCTASE, ALDO/KETO REDUCTASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR43638:SF3; OXIDOREDUCTASE, ALDO_KETO REDUCTASE FAMILY PROTEIN; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 2.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000182719}.
FT DOMAIN 16..268
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 52
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 111
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 78
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 282 AA; 30928 MW; 86EC672525378D93 CRC64;
MERRVFGTAG VSVPVIGQGT WQMENDDRDG AIRALQAGMD LGLIHLDTAE LYGRGRVEES
IVAPAIAGRR DSVFLVSKVM PSNATYEGTV KACERSLQRL KTDRLDCYLL HWPGSHPLEH
TLRAFEVLVR DGKIRSWGVS NFGVEELEEA VRIAGPGRIV CNQVLYHLEE RAIEHKVLPW
CERANIAVVG YSPFGNGRFP RPDSAGGRVL ALVAQAHGAS PYQVALQFLV RRPGLFTIPK
ASREPHVRDN AAAAGLRLSP EELARIDAAF PRGPDTGELP VI
//
