ID   A0A1H7UKR2_9SPHN        Unreviewed;      1314 AA.
AC   A0A1H7UKR2;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=SAMN05216382_3024 {ECO:0000313|EMBL:SEL97389.1};
OS   Sphingomonas palmae.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingomonas.
OX   NCBI_TaxID=1855283 {ECO:0000313|EMBL:SEL97389.1, ECO:0000313|Proteomes:UP000199214};
RN   [1] {ECO:0000313|Proteomes:UP000199214}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JS21-1 {ECO:0000313|Proteomes:UP000199214};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR   EMBL; FNZZ01000007; SEL97389.1; -; Genomic_DNA.
DR   STRING; 1855283.SAMN05216382_3024; -.
DR   OrthoDB; 9806213at2; -.
DR   Proteomes; UP000199214; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR046816; MmeI_Mtase.
DR   InterPro; IPR046820; MmeI_TRD.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR   PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   Pfam; PF20473; MmeI_Mtase; 1.
DR   Pfam; PF20466; MmeI_TRD; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:SEL97389.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199214};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          528..646
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
FT   DOMAIN          813..916
FT                   /note="MmeI-like DNA-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF20473"
FT   DOMAIN          1080..1193
FT                   /note="MmeI-like target recognition"
FT                   /evidence="ECO:0000259|Pfam:PF20466"
SQ   SEQUENCE   1314 AA;  143132 MW;  E904F37F74E007C0 CRC64;
     MARDVSAPLP NAHDWIGYLQ PVGLVIAPAA LSRIGLWPAP QTAADTSAVA DALGAETWPL
     FRDVLGWPAD RVAGAPGGSA LPEACRFAFT EQDTLLEPDW AVLDADGAPL LLVRIEQPDL
     VLDRRGTLDG WEATAQQRFE RLLRETGVLA GVLIGARETG RVEGEATEPV LRLVVAPRGE
     ASGHITWPLA ALATTGGRAM LAGLKLLLDA HALFTGPPSH RLPTILAESR AAQADVSSRL
     SGQVLASLHE LLRGLDAAAP DRIRALTLRD PQHLYEGVLT VLLRLIFILY AEDRGLMPSA
     AGGAAASLYE QGYALGGLHL RLRDDHALYP DTIDERRGAW GRLLALFRLV DRGHPSGFMQ
     ARGGTLFDEH AFPFLLGRDT AGDAEQVLAV SDGCVLRVLD NLLMLGGERV AYRALSVEQI
     GAVYETVMGF TAICAPAPML AIRAGKNNRV PVWVNLAALA TTKPGEREKW LKAATGRGAF
     PAAVAQGLRT ADGIDALGLA LAPIADLRAC PRRTPVAAGT PVLQPTDERR RTGSHYTPRA
     LTQPIVTHAL APAFARIGAD ARPADVLDLK VCDPAAGSGA FLVEACRQLG ERLVTAWARW
     PAQRPTIPAD EDELLHAKRL VAQHCLRGVD RNPLAIDLAK LSLWLETLAS AHEFTFLDGV
     LRSGDSLVGL PNPNIVAVTW GRVSQQHGFV EAIVREGIDA AAELRRLMRV EAEIAPYAAQ
     ERRHRAAATA LKRAHLVADA VLHAFFSGTS KRDRDARLAE VQQCVLAPTD ASWARLEEWQ
     RALHDPLIGI TPFHWELEFE DVFARPNPGF DAIIGNPPFA GKNTIAAGHA AAYPDWLKAL
     HANAHGNADL CAHFFRRAFS LLRRGGAFGL IATNTIRQGD TRETGLAQIL ADGGTITRAI
     SRHRWEGEAA VVVAQVFVQR GPVAPDTVPI LDHRPVRRIS AYLMEGDLDA SPAALRENAG
     TAFIGSFLLG MGFTFDDVNA ANGIATPIAN MRYLLATDPQ NASVIKPYLG GEEINNSPSF
     SHHRYVIDFA DRPLSRETDG SSWYDLTATE QLQQQRGGIV AKDYPGRVAA DWPDLLKIIM
     QKVKPERLKQ NDANGKRLWW RHLRTRPELY QTTGLLSHVL AVNCGATPHV CFARLPTGPT
     FSHTTAVFAL PTFAAFATLQ SRVHEVWARF FASSMKDDLR YTPSDCFETF PLPPGYADAP
     ALEHAGQRYH DARAALMIAR GEGMTPTYNR FHRATDQADD IAALRALHHV IDRAVLTAYG
     WHDLAEAAAP VFLDTDEDDH RYQRRLFWPA PFRDAVLARL LRLNQERARM EQLS
//