ID   A0A1H7V064_9PAST        Unreviewed;       386 AA.
AC   A0A1H7V064;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Membrane fusion protein, multidrug efflux system {ECO:0000313|EMBL:SEM02137.1};
GN   ORFNames=SAMN05444853_10375 {ECO:0000313|EMBL:SEM02137.1};
OS   Pasteurella skyensis.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Pasteurella.
OX   NCBI_TaxID=97481 {ECO:0000313|EMBL:SEM02137.1, ECO:0000313|Proteomes:UP000198883};
RN   [1] {ECO:0000313|Proteomes:UP000198883}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 24204 {ECO:0000313|Proteomes:UP000198883};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000256|ARBA:ARBA00009477}.
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DR   EMBL; FOBN01000003; SEM02137.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H7V064; -.
DR   STRING; 97481.SAMN05444853_10375; -.
DR   OrthoDB; 9811754at2; -.
DR   Proteomes; UP000198883; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR   Gene3D; 2.40.30.170; -; 1.
DR   Gene3D; 2.40.50.100; -; 1.
DR   InterPro; IPR043602; CusB_dom_1.
DR   InterPro; IPR032317; HlyD_D23.
DR   InterPro; IPR005694; MFP_proteobact.
DR   NCBIfam; TIGR00998; 8a0101; 1.
DR   PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR   PANTHER; PTHR30386:SF19; MULTIDRUG EXPORT PROTEIN EMRA-RELATED; 1.
DR   Pfam; PF00529; CusB_dom_1; 1.
DR   Pfam; PF16576; HlyD_D23; 1.
DR   SUPFAM; SSF111369; HlyD-like secretion proteins; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          55..286
FT                   /note="RND efflux pump membrane fusion protein barrel-
FT                   sandwich"
FT                   /evidence="ECO:0000259|Pfam:PF16576"
FT   DOMAIN          287..340
FT                   /note="Cation efflux system protein CusB"
FT                   /evidence="ECO:0000259|Pfam:PF00529"
FT   COILED          95..136
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   386 AA;  43096 MW;  D6C928326B50E00A CRC64;
     MSETGSDLSK KKQRTKTFSL FFGLLFIIIV IVSICWLFLF KGYETTDDAY VVGNQVMITP
     KVAGNVVQIN VENMDFVHKG DVLVVLDNSD KELALKQAET ALASAVRNIQ QLNYSVKQLQ
     ETVKGKQIAL AQAKSDLARR QKLAKTHSID QESVQHAKDK MTMAYANLQL AKLQLASSKA
     LLQQMPLIEQ PTIQNAIASV KQAWLKLKRT QILSPVEGYV AKRNVQLGAS VGTNSPLMAI
     IPPYQFWIDA NFKETQLKNI RIGQPVKITV DMYGDDVKFD GKVTGIALGT GSAFSLLPAQ
     NATGNWIKIT QRVPVRIELD PKQLEKYPLR MGLSASVKIE VTNKDGDVLL QQKRSTPLYT
     TDALEYEQSE IEQRISHIIK QNINEH
//