ID   A0A1H7X8P2_9BACI        Unreviewed;       344 AA.
AC   A0A1H7X8P2;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN   ORFNames=SAMN05192533_102101 {ECO:0000313|EMBL:SEM30242.1};
OS   Mesobacillus persicus.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Mesobacillus.
OX   NCBI_TaxID=930146 {ECO:0000313|EMBL:SEM30242.1, ECO:0000313|Proteomes:UP000198553};
RN   [1] {ECO:0000313|Proteomes:UP000198553}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B48,IBRC-M 10115,DSM 25386,CECT 8001
RC   {ECO:0000313|Proteomes:UP000198553};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; FOBW01000002; SEM30242.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H7X8P2; -.
DR   STRING; 930146.SAMN05192533_102101; -.
DR   Proteomes; UP000198553; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   NCBIfam; TIGR00331; hrcA; 1.
DR   PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR   PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000198553};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW   Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW   Rule:MF_00081};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW   Rule:MF_00081};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW   Rule:MF_00081}.
FT   DOMAIN          105..323
FT                   /note="Heat-inducible transcription repressor HrcA C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01628"
SQ   SEQUENCE   344 AA;  38501 MW;  8E0E9BC634DB62B8 CRC64;
     MLLTDRQVLI LQVIVDDFIR TAQPVGSRSL SKKDEISFSS ATVRNEMADL EELGFIEKTH
     TSSGRIPSEK GYRYYVDHLL LPQKLNRSEI QSVRSIFAEQ IYELEKIVQK SAKILSELTS
     YTSIVLGPAV NNNKLKRIQI VPLNQDTAIA IIVTDTGHVE NRVFHFPASV DPGDVEKMVN
     ILNERLAGVP LINLNGRIYK EVASILRQHI KSYDVLMGSI SETLSIPASD KVFFGGKTNM
     LNLPDFNDIE KIRNLMAMIE QEDGISQLIR RNPKGLNVKI GRENDNSAME DCSLITATYS
     IGSEKLGTIA VLGPTRMEYS RVISLLEFIS ADLSKVLTDL YQNN
//