ID A0A1H7ZDV9_9ACTN Unreviewed; 681 AA.
AC A0A1H7ZDV9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:SEM55699.1};
GN ORFNames=SAMN05660976_05483 {ECO:0000313|EMBL:SEM55699.1};
OS Nonomuraea pusilla.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Nonomuraea.
OX NCBI_TaxID=46177 {ECO:0000313|EMBL:SEM55699.1, ECO:0000313|Proteomes:UP000198953};
RN [1] {ECO:0000313|EMBL:SEM55699.1, ECO:0000313|Proteomes:UP000198953}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43357 {ECO:0000313|EMBL:SEM55699.1,
RC ECO:0000313|Proteomes:UP000198953};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; FOBF01000014; SEM55699.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H7ZDV9; -.
DR STRING; 46177.SAMN05660976_05483; -.
DR OrthoDB; 9766847at2; -.
DR Proteomes; UP000198953; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000198953}.
FT DOMAIN 51..234
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 278..649
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 681 AA; 73296 MW; 8DC9A24930FA76FE CRC64;
MMRMRARLLV LQVLVLALLV VLAGRLWQVQ VVRGQEFVQR ATETRTRTVL VPAVRGQILD
ASGRPLVRNK TALVVSVDRT RLARTPDGGA GVLAKLSKVL GRPVQDLQRR ITPCAPKVPK
PCWTGSPYQP VPLDEKVSTR EALQILERQE EFPGVTAEVH SVREYPGGRA GAQMLGYLQP
VTEAELEKRE GLKASFSGVD LAGRDGLEYV YDDELRGKSG LRRVQVDRMG KALGVEEQTA
PVAGDTIVTS IDSRVQAVVE KALAHAMKAQ PSADGAAGVV LDVRTGRVVA LASAPGYDPA
IWAGGISARG YQWLLSDKSG KPLVSRAING QFAPGSTFKI SSVSAMLRAG YPLNGTYDCP
GSYMVGDRAF NNFRGQGLGT MSLHTALVKS CDTIFYRAAY EQYLKDGGRN PKKHPKEIFA
NTARAFGFGK PTGIDLPGES SGRIPDRAWK KDLWARTSAI SCKRSRTGYP EEKDAARAAF
LKRLALENCT EGFLLRPGDS ANFSIGQGDV LVTPVQLARA YMALVGDGRL RSPRIAWAQV
RPDGTVVKTF DVPVVGKLPL SEKERLYIKG ALSDVASDGT AAGAFAGFPM DRVRVGGKTG
TAEVWGKKDT SWFASFAPTD HPQFVVVVMV SQGGMGAETA APAVREIYEG IYGIKGPAAL
PGGRPVSRLP RFAPDGTVIR E
//
