ID A0A1H7ZYD8_9RHOB Unreviewed; 612 AA.
AC A0A1H7ZYD8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=SAMN04488103_101668 {ECO:0000313|EMBL:SEM62608.1};
OS Gemmobacter aquatilis.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Gemmobacter.
OX NCBI_TaxID=933059 {ECO:0000313|EMBL:SEM62608.1, ECO:0000313|Proteomes:UP000198761};
RN [1] {ECO:0000313|EMBL:SEM62608.1, ECO:0000313|Proteomes:UP000198761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 3857 {ECO:0000313|EMBL:SEM62608.1,
RC ECO:0000313|Proteomes:UP000198761};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
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DR EMBL; FOCE01000001; SEM62608.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H7ZYD8; -.
DR STRING; 933059.SAMN04488103_101668; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000198761; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000198761}.
FT DOMAIN 226..344
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 426..569
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 612 AA; 65696 MW; DA0463F43F8033C6 CRC64;
MKLDTPQIAR PVIRQLDEAA INRIAAGEVV ERPASAVKEL VENALDAGAR RITVDYADGG
KTLIRVTDDG CGMTAEDLPL ALSRHATSKI DGSDLLNIRS FGFRGEALPS LGAVGRLTLT
SRAEGHDGVS LSVEGGRMGA PRPAALSRGT VVELRDLFFA TPARLKFMRS DRSEMGAIAD
VVKRLALAEP HVGFILRDVS GGGEGRVVFR ADPENGDFFD ALHGRLSRVL GADFTDNALR
IDLEREGLHL VGYAALPTYS RGSSAAQFLF VNGRPVLDKM LFGALRAAYM DVLSRDRHPA
AVLNLICDPE RVDVNVHPAK SEVRFREPAL ARGLIVSGLR LALGGAGHRA SSTVADETLA
AFQPEPQQAS GFPRVYQMDR PSQPSLMRAY TAQAPEGFGF AEAPSARVEA VAAPEPDLTE
RPLGAARAQV HENYIIAQTT RGMVIVDQHA AHERLVYERL KAQAADKGIA AQALLIPEIV
DLSEADAARL LDIAPDLAAL GLVVEPFGGG AVAVREVPAI LGRVDASALI RDIVDDLADL
GSSERLKGRI DAVLSRMACH GSIRSGRQMR ADEMNALLRE MEATPLSGQC NHGRPTYVEL
KLADIERLFG RR
//
