ID A0A1H8AL71_9BACL Unreviewed; 548 AA.
AC A0A1H8AL71;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=SAMN05444955_101222 {ECO:0000313|EMBL:SEM71490.1};
OS Lihuaxuella thermophila.
OC Bacteria; Bacillota; Bacilli; Bacillales; Thermoactinomycetaceae;
OC Lihuaxuella.
OX NCBI_TaxID=1173111 {ECO:0000313|EMBL:SEM71490.1, ECO:0000313|Proteomes:UP000199695};
RN [1] {ECO:0000313|EMBL:SEM71490.1, ECO:0000313|Proteomes:UP000199695}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 46701 {ECO:0000313|EMBL:SEM71490.1,
RC ECO:0000313|Proteomes:UP000199695};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; FOCQ01000001; SEM71490.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H8AL71; -.
DR STRING; 1173111.SAMN05444955_101222; -.
DR OrthoDB; 9802848at2; -.
DR Proteomes; UP000199695; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd18029; DEXHc_XPB; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000199695}.
FT DOMAIN 195..351
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 406..548
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 548 AA; 62750 MW; 860C6A0F36228F88 CRC64;
MTSRIHHPLL VTSDRMIRVE VNHPAYHEVR KQLVRFAERV KSPSNLHTYR MTPYTLWNAA
VQNLTPGDIL EWLEKMSKLP VPSSVATEVK EWMGRYGMLR LERVDSSSFQ LISVQPEYIQ
KIMDQTAIRE WSIERPGENA LLFPLQARGQ VKQACTQAGY PVIDQIGFQE GESLSIRLSK
HSRTGAFTLR DYQKQAVEAF GGNGVIVLPC GAGKTVVGIA AMEKVGKATL ILTPNATSAK
QWIREILDKT DLPEEAVGEY TSECKKVRPV TVTTYQMMTR RTDRNGPFHH MKLFSERDWG
LIIYDEVHLL PAPVFRATAA LQAKRRLGLT ATLIREDGKE GEVFSLIGPK LFEVSWGELE
DQGWIAEAVC TEIRVPFSDP ERERYTRSSH RQKYRLAAEN PNKMKVIDQL IRRHRGEQIL
VIGQYLDQLQ QLAERYQAPI ITGQMKQEKR ESWFERFRNK EISLLIVSKV ANFAVDLPDA
AVAIQISGTF GSRQEEAQRL GRILRPKAGD NRAYFYHVVT KDTLDQEYAM NRQLFLAEQG
YSYQIHEM
//
