ID A0A1H8C883_9RHOB Unreviewed; 1812 AA.
AC A0A1H8C883;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Apple domain-containing protein {ECO:0000259|PROSITE:PS50948};
GN ORFNames=SAMN05216227_100489 {ECO:0000313|EMBL:SEM91089.1};
OS Pseudorhodobacter antarcticus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Pseudorhodobacter.
OX NCBI_TaxID=1077947 {ECO:0000313|EMBL:SEM91089.1, ECO:0000313|Proteomes:UP000183002};
RN [1] {ECO:0000313|EMBL:SEM91089.1, ECO:0000313|Proteomes:UP000183002}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.10836 {ECO:0000313|EMBL:SEM91089.1,
RC ECO:0000313|Proteomes:UP000183002};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
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DR EMBL; FOCO01000004; SEM91089.1; -; Genomic_DNA.
DR RefSeq; WP_074818400.1; NZ_FOCO01000004.1.
DR STRING; 1077947.SAMN05216227_100489; -.
DR Proteomes; UP000183002; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR CDD; cd01100; APPLE_Factor_XI_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 1.
DR InterPro; IPR026284; A2-macglob_dom_prot_bac.
DR InterPro; IPR049120; A2M_bMG2.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR000177; Apple.
DR InterPro; IPR041203; Bact_A2M_MG5.
DR InterPro; IPR041462; Bact_A2M_MG6.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF21142; A2M_bMG2; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF17972; bMG5; 1.
DR Pfam; PF17962; bMG6; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF14295; PAN_4; 1.
DR Pfam; PF07678; TED_complement; 1.
DR PIRSF; PIRSF038980; A2M_bac; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM00223; APPLE; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS50948; PAN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000183002};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1812
FT /note="Apple domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010213013"
FT DOMAIN 28..106
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
SQ SEQUENCE 1812 AA; 188219 MW; F33D3922AFEBAE3C CRC64;
MAYFLKSVGG AVLAGLLAMT GASAQDLVPA KRFMLSQDVD LPGGDIASLF DTDLAACQVA
CLANTSCTAI TFNARNGSCF LKAGAGAGVP YAGAISGDVL VAGRGAQDLA QVRAAELDFL
GAGDFDVARA QAVGLAAQHL TGGWTAADLL AAAQDTGAQD TGGDVARAAG LVGAAINITD
AAGDWAEYGR LLAVAALGDA DNRGALQARA LAASVNGYVR ADGAGLRHSI LVQMAEVLEA
QGRGADMVPA LRLAQAVQPR VDTEVALGVA MGKYGFRVME NDVQSDSARP RICAQFSGDL
AKGVDFNPFV QMDAAGLTVE RNGDRSLCVE GVAHGARYAL TFRAGIPAAD GQVTARPVTI
TAYVRDRSPV LRFGGRAYVL PRAGDAALPI ESVNAAQADL TLYRVTDRNI LRAVQEGMLS
EPIRFWQEDG FANGIGAQIW AGQADLAMEV NRDMTTRLPM AEALAGQGAG IFVLRAALPG
KAADEVAPAW QWFVVSDLGI STLSGIDGLH VVVRSLGTAG AKPGVTVELL SRGNEVLGTA
QTDAQGFVTF AAGLTRGVGA QGPAMVVVRD GADDTAFMSL TDPEFDLSDR GVEGREAAPP
MDVFLTTDRG AYRAGEVVYA TALTRDGDAR AIAGVPLTAI AKRPDGVEYS RAVASDAGAG
GHVFAVPIAG SAPRGTWRLE VLADLEAAPL TSRTFLVEDF LPERIDFTLT LPDAPLRLGD
APELTVEAKY LFGAVGADLA IEGDVILRAA KGLAAYPGYA FGLANEPFST RVEGFGGAVT
DAQGRAVVTL AMPQVDDPAR PLEVVVVARV AEGSGRPVER RLMTPLSPAA AMIGVKPLFD
GVVAEGAEAR FSLLAVGADG PVAMPVAWEL SRIETRYQWY QEFGNWNWEP VTSRERVAEG
VSELGAAVEI GAAVSWGEYE LVVTQAGGAA ATSTRFYAGW YAPADVTSTP DTLELSLDKA
AYKPGDVAQL RIVPRAAGVA LVSVLSNRVV SMQMVDVVAG ENTIALDVTD DWGAGVYVTA
SVLRPMDVAA GRNPARAMGL AHAAIDPGDR ALLATVEVAA EVAPRGPMEV AVRVDGLRAG
DTAFATIAAV DVGILNLTSF GVPDPKAHYF GQRKLGVGLR DVYGRLIDGL NGAVGVVRSG
GDAAAQARLE APPPTEELVA YFIGPVTVGA DGLARASFDL PSFNGTVRVM AVVWSQAGVG
QASADVLVRD PVVVTASVPR FLSPGDESRM LLEVVHATGP AGRMGLDVTA ARLALGAVPS
GFELAVGGKA VFEVPITAGV EGVQEVSVAL TTPDGKQLTK VLRIPVQRGD PEIARSSRLD
LAAGAVFTLD QSVFDGFAPG SGLATMAVGP IARLDAPGLL AALDRYPYGC TEQVTSRALP
LIYFDQVAQA MQMKGAENIG VRIAEAVGAV LTNQTSEGGF GLWGPSAGDF WLDAYVTDFL
SRARAQGHAV PDVAFRSALD NLRNQVNYTA DFDEGGEALA YALMVLAREG AAAIGDLRYY
ADVKGDAFAT PIAQAQLGAA LASYGDQRRA DAMFARAGAR IAADGLEEAQ VYRADYGTAR
RDAAAVLTLA VEAGSEVVDR DALALALRPD GRAMSTQESV WTLLAANALI DRAGAEGITL
NGQPVDGPLV RVLRAGADAP VAVANGGAAT VLTVTAYGVP EVAGPASGNG YAITRQYFTM
EGDAISLDQG VQAGDRMVVM LQVQPFGTAQ ARLIVADPLP AGFEIDNPNL LRGGEVGGLG
WLDVLDSTEH SEFRQDRFIS AVDWEGRDTF RLAYVVRAVS PGSFHHPAAS VEDMYRPDYR
AQTDAGRVVI AP
//
