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Database: UniProt
Entry: A0A1H8CIW4_9FIRM
LinkDB: A0A1H8CIW4_9FIRM
Original site: A0A1H8CIW4_9FIRM 
ID   A0A1H8CIW4_9FIRM        Unreviewed;       448 AA.
AC   A0A1H8CIW4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   13-FEB-2019, entry version 11.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=SAMN05216180_2157 {ECO:0000313|EMBL:SEM94926.1};
OS   Hydrogenoanaerobacterium saccharovorans.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae;
OC   Hydrogenoanaerobacterium.
OX   NCBI_TaxID=474960 {ECO:0000313|EMBL:SEM94926.1, ECO:0000313|Proteomes:UP000199158};
RN   [1] {ECO:0000313|EMBL:SEM94926.1, ECO:0000313|Proteomes:UP000199158}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.5070 {ECO:0000313|EMBL:SEM94926.1,
RC   ECO:0000313|Proteomes:UP000199158};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; FOCG01000002; SEM94926.1; -; Genomic_DNA.
DR   BioCyc; GCF_900110045:BMX31_RS10650-MONOMER; -.
DR   Proteomes; UP000199158; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000199158};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199158}.
FT   DOMAIN      142    272       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      354    424       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     150    157       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
FT   COILED      304    324       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   448 AA;  50687 MW;  EC227B263F91248E CRC64;
     MESFREVFSL VSEYCKKEIS QVAHSLWIKD IEPVKLEDST AYLAVRSEFK QKILEEKYYD
     LLSRAFEEVM GFHVDIVISS LEPTKAQAEE AVVKLSHCSP EELEKTTAGG DYEYTFNTFI
     VGPSNKFAHA ASLAVATNPA GAYNPLFIYG GSGLGKTHLL YAICNEILKT SPQSNIIYVK
     GEDFTNELIE AIRSETTKEF HSKYRQAEVL LVDDIQFIGG KESTQEEFFH TFNSLYEAGK
     QIVLTSDRPP KEIKTLEDRL RTRFEWGLLA DVQPPDFETR IAIIRRKAEL LDINIPDDVA
     EYMANKLKTN IRQLEGAVKK LKAYKLLAGT PPSILIAQNA IRDILNDHQP VPVTIERIIS
     EVARTYNGVS PQDIRSSKRS ANISSARQVS IYIVREITQM SMSAIGEEFG GRDHSTIVYA
     IQQVEKNMDV DPRYKELIED IIKNVRNS
//
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