ID A0A1H8D2H2_9FIRM Unreviewed; 507 AA.
AC A0A1H8D2H2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Cardiolipin synthase {ECO:0000313|EMBL:SEN00904.1};
GN ORFNames=SAMN05216180_2452 {ECO:0000313|EMBL:SEN00904.1};
OS Hydrogenoanaerobacterium saccharovorans.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Hydrogenoanaerobacterium.
OX NCBI_TaxID=474960 {ECO:0000313|EMBL:SEN00904.1, ECO:0000313|Proteomes:UP000199158};
RN [1] {ECO:0000313|EMBL:SEN00904.1, ECO:0000313|Proteomes:UP000199158}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.5070 {ECO:0000313|EMBL:SEN00904.1,
RC ECO:0000313|Proteomes:UP000199158};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FOCG01000002; SEN00904.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H8D2H2; -.
DR STRING; 474960.SAMN05216180_2452; -.
DR OrthoDB; 9762009at2; -.
DR Proteomes; UP000199158; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0008808; F:cardiolipin synthase activity; IEA:InterPro.
DR GO; GO:0032049; P:cardiolipin biosynthetic process; IEA:InterPro.
DR CDD; cd09154; PLDc_SMU_988_like_1; 1.
DR CDD; cd09160; PLDc_SMU_988_like_2; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR022924; Cardiolipin_synthase.
DR InterPro; IPR027379; CLS_N.
DR InterPro; IPR025202; PLD-like_dom.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR NCBIfam; TIGR04265; bac_cardiolipin; 1.
DR PANTHER; PTHR21248; CARDIOLIPIN SYNTHASE; 1.
DR PANTHER; PTHR21248:SF22; PHOSPHOLIPASE D; 1.
DR Pfam; PF13091; PLDc_2; 2.
DR Pfam; PF13396; PLDc_N; 1.
DR SMART; SM00155; PLDc; 2.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50035; PLD; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000199158};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 37..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 244..271
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT DOMAIN 420..447
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
SQ SEQUENCE 507 AA; 58834 MW; D33034EBC07C4315 CRC64;
MKKIIKFLFS RMVIVGLLIA VQLAFIVVLI LSLSEKWVYV FWGLQVASLF VVLWIISKTD
NPSYKLAWCI SILLLPLFGG LFYLMFGNKS LNKKLKTKIA DYAYDQYHHF DENEKIHSEL
QEYNPLLYRQ SEYITRISGF PACKNTEASY FPLGEDKWVV LLQELKKAKK FIFMEYFIVR
QGKMWDPVYE ILKQKSAEGV EVKFMYDDLG SIQTLPTGYD KIMRKAGIEV TVFNPFRPRL
TSAMNYRDHR KITVIDGNVG FCGGINLADE YINAYEKHGH WKDTAVVLRG EAVRNLTLMF
IHLWEFSNDI SIDLDRYMPT ERYESDGYIQ PFGDSPIDDY NVAENAYMQM INCAKKYVYI
TSPYLILDNE MITALCLAAQ SGIDVRIITP HIADKWYVHM VTQSYYAQLI QSGVKIYEYT
PGFIHAKMFV CDDEIAIVGT TNMDYRSFYL HFECGVSFYR SSIVGEVKRD ILNTIAISQE
ITLEASRGIK RRFRLTRSIL RGFAPLM
//
