ID   A0A1H8DDR7_9BURK        Unreviewed;      1035 AA.
AC   A0A1H8DDR7;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Cobalt-zinc-cadmium resistance protein CzcA {ECO:0000313|EMBL:SEN04708.1};
GN   ORFNames=SAMN05216319_5284 {ECO:0000313|EMBL:SEN04708.1};
OS   Duganella sp. CF402.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Oxalobacteraceae; Telluria group; Duganella.
OX   NCBI_TaxID=1855289 {ECO:0000313|EMBL:SEN04708.1, ECO:0000313|Proteomes:UP000198529};
RN   [1] {ECO:0000313|Proteomes:UP000198529}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CF402 {ECO:0000313|Proteomes:UP000198529};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
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DR   EMBL; FOBG01000004; SEN04708.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H8DDR7; -.
DR   STRING; 1855289.SAMN05216319_5284; -.
DR   Proteomes; UP000198529; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004763; CusA-like.
DR   NCBIfam; TIGR00914; 2A0601; 1.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        395..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        452..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        484..509
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        530..552
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        876..893
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        900..922
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        928..950
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        971..991
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1003..1026
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1035 AA;  111321 MW;  839CD4421FFC052B CRC64;
     MFERLIRYAI AQRWLVLLLV AALAALGVYS YQKLPIDAVP DITNVQVQIN TAAPGYAPLE
     TEQRVTYPLE NVLAGLPRLE QTRSLSRYGL SQITVVFKDG TDLYFARQLV SERLQQARGQ
     LPAGITPALG PISSGLGEIY LWTVEARPDA RKADGTPYTP TDLREIQDWI VKPQLRNVAG
     VTEINAIGGY AREYHVAPQP QRLAAYGLTL QELVTALERN NGNAGAGYIE KRGEQLLVRA
     PGQVRSLDDI RDIVLRSADG VPVRVRDVAE VALGRELRTG AATENGREVV LGTVFMLIGQ
     NSRAVAQAVD KQMAAINRSL PPGVLAITVY DRTALVDKAI GTVKKNLLEG AVLVIAVLFL
     FLGNLRAALI TAMVIPLSML FTFSGMVAYK VSANLLSLGA LDFGIIVDGA VVIVENCVRR
     LALAQATLGR PLTRAEKFEE VFGAAQEARR PLLFGQLIIM VVYLPIFALT GVEGRMFHPM
     ALTVVMALAG AMLLSVTFIP AAVALFIGDH VVEKHTPRIS AWYGALLERA LANAPVVLSF
     AGIAVALSLL LATRMGSEFV PSLNEGDIAM QALRIPGTSL TQSVAMQQQI ELTLMRKFPE
     IERVFARTGT AEIASDPMPP NISDGYIMLK PEAQWPKPKK SRDELLAAIQ ATVAQLPGNA
     YEFSQPIQLR FNELISGVRS DVAVKLFGDD AQVLEAVSAR VAAALAKVDG AQEVKVEQTS
     GLPVLTIDID RSKTARYGLN VSDVQDVIAT AVGGREAGTM FEGDRRFAIV VRLPEALRGD
     VDAMRRLPLP LPGSSANFIP LGEVASFSVA PGPNQISREN GKRRVVISAN VRGRDIGSFV
     AEAEKRLQEV KIPAGYWTMW GGQFEQLQSA SQRLRIVVPA ALALVMLLLF AMFGNLRDGL
     LVFSGIPFAL TGGLAALALR GIPLSISAAV GFIALSGVAV LNGLVLISAI RKLREDGRSV
     EQAIREGALS RLRPVLMTAL VASLGFIPMA IATGTGAEVQ RPLATVVIGG ILSSTALTLL
     VLPLLYRWVV FKKAL
//