ID A0A1H8DZJ4_9BACL Unreviewed; 548 AA.
AC A0A1H8DZJ4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Precorrin-3B C17-methyltransferase {ECO:0000313|EMBL:SEN12623.1};
GN ORFNames=SAMN05444955_10656 {ECO:0000313|EMBL:SEN12623.1};
OS Lihuaxuella thermophila.
OC Bacteria; Bacillota; Bacilli; Bacillales; Thermoactinomycetaceae;
OC Lihuaxuella.
OX NCBI_TaxID=1173111 {ECO:0000313|EMBL:SEN12623.1, ECO:0000313|Proteomes:UP000199695};
RN [1] {ECO:0000313|EMBL:SEN12623.1, ECO:0000313|Proteomes:UP000199695}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 46701 {ECO:0000313|EMBL:SEN12623.1,
RC ECO:0000313|Proteomes:UP000199695};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FOCQ01000006; SEN12623.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H8DZJ4; -.
DR STRING; 1173111.SAMN05444955_10656; -.
DR OrthoDB; 9772960at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000199695; Unassembled WGS sequence.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd11646; Precorrin_3B_C17_MT; 1.
DR Gene3D; 3.30.413.10; Sulfite Reductase Hemoprotein, domain 1; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006363; Cbl_synth_CobJ/CibH_dom.
DR InterPro; IPR006067; NO2/SO3_Rdtase_4Fe4S_dom.
DR InterPro; IPR045854; NO2/SO3_Rdtase_4Fe4S_sf.
DR InterPro; IPR006066; NO2/SO3_Rdtase_FeS/sirohaem_BS.
DR NCBIfam; TIGR01466; cobJ_cbiH; 1.
DR PANTHER; PTHR47036; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR47036:SF1; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR Pfam; PF01077; NIR_SIR; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF56014; Nitrite and sulphite reductase 4Fe-4S domain-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00365; NIR_SIR; 1.
PE 4: Predicted;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SEN12623.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199695};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SEN12623.1}.
FT DOMAIN 6..217
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 425..525
FT /note="Nitrite/sulphite reductase 4Fe-4S"
FT /evidence="ECO:0000259|Pfam:PF01077"
SQ SEQUENCE 548 AA; 59930 MW; BEA2A7CDB0AD8091 CRC64;
MSKKGKLLIV GFGPGHFAHI TERARQAIQE SEVIVGYNTY VDLIREILTD QEIVRTGMTE
EVSRAQEAVR RAEQGKTVAV ISSGDAGLYG MAGLVYEVLI EKGWRPGSGV EVEVIPGISA
IHSCASLLGS PVMHDACTIS LSDHLTPWET IAKRIEAAAA ADFVIALYNP KSGRRTRQIV
ETQRILLKYR SPETPVGLVK SAYRERQNIV LTTLAEMLNH EIGMLTTVII GNSTTFVYEG
LMITPRGYQR KYTLSKEVQD LKPHQRLQVE AEPWSLNALE RMQEHKETPK MTSTEVVDEE
TAHPVQLAEE ALAVLQAKGL AATRIDSMPA GIPVSILEVA VSPGIANKKI TPEQLVLLAE
IAGDQGEIEY TPHHQLILRV PTDQPGQVAD RLAAAGMLLS PVGDVVQLKA CDFCDGDKGE
AIPYAEELHR RLSGLQVPKE LKIGFNGCAM ACYGAVTEEI GIVYRRGTFD LFLGGKNIGR
NAHPAQRVAE GIPPEQLIGA VEQVVREYAA QGHPNERFNK FFKRVKEVAG FMYSDEGKPV
VAELACGD
//
