ID A0A1H8E7C6_9FIRM Unreviewed; 731 AA.
AC A0A1H8E7C6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Alpha-galactosidase {ECO:0000256|ARBA:ARBA00012755, ECO:0000256|PIRNR:PIRNR005536};
DE EC=3.2.1.22 {ECO:0000256|ARBA:ARBA00012755, ECO:0000256|PIRNR:PIRNR005536};
GN ORFNames=SAMN05216180_2917 {ECO:0000313|EMBL:SEN15405.1};
OS Hydrogenoanaerobacterium saccharovorans.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Hydrogenoanaerobacterium.
OX NCBI_TaxID=474960 {ECO:0000313|EMBL:SEN15405.1, ECO:0000313|Proteomes:UP000199158};
RN [1] {ECO:0000313|EMBL:SEN15405.1, ECO:0000313|Proteomes:UP000199158}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.5070 {ECO:0000313|EMBL:SEN15405.1,
RC ECO:0000313|Proteomes:UP000199158};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing alpha-D-galactose
CC residues in alpha-D-galactosides, including galactose
CC oligosaccharides, galactomannans and galactolipids.; EC=3.2.1.22;
CC Evidence={ECO:0000256|ARBA:ARBA00001255,
CC ECO:0000256|PIRNR:PIRNR005536};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase.
CC {ECO:0000256|PIRNR:PIRNR005536}.
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DR EMBL; FOCG01000005; SEN15405.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H8E7C6; -.
DR STRING; 474960.SAMN05216180_2917; -.
DR OrthoDB; 9758822at2; -.
DR Proteomes; UP000199158; Unassembled WGS sequence.
DR GO; GO:0004557; F:alpha-galactosidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016052; P:carbohydrate catabolic process; IEA:InterPro.
DR CDD; cd14791; GH36; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 2.70.98.60; alpha-galactosidase from lactobacil brevis; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR038417; Alpga-gal_N_sf.
DR InterPro; IPR000111; Glyco_hydro_27/36_CS.
DR InterPro; IPR002252; Glyco_hydro_36.
DR InterPro; IPR031705; Glyco_hydro_36_C.
DR InterPro; IPR031704; Glyco_hydro_36_N.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR43053:SF3; ALPHA-GALACTOSIDASE-RELATED; 1.
DR PANTHER; PTHR43053; GLYCOSIDASE FAMILY 31; 1.
DR Pfam; PF16874; Glyco_hydro_36C; 1.
DR Pfam; PF16875; Glyco_hydro_36N; 1.
DR Pfam; PF02065; Melibiase; 1.
DR PIRSF; PIRSF005536; Agal; 1.
DR PRINTS; PR00743; GLHYDRLASE36.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR PROSITE; PS00512; ALPHA_GALACTOSIDASE; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|PIRNR:PIRNR005536};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR005536};
KW Reference proteome {ECO:0000313|Proteomes:UP000199158}.
FT DOMAIN 30..285
FT /note="Glycosyl hydrolase family 36 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16875"
FT DOMAIN 649..726
FT /note="Glycosyl hydrolase family 36 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16874"
FT ACT_SITE 479
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR005536-1"
FT ACT_SITE 549
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005536-1"
SQ SEQUENCE 731 AA; 84628 MW; 870128BC8C714586 CRC64;
MAIEFLNRQG IFHLATNNTS YVIKLWQNTY PMHVYWGERI ANPNIDWHLE TPYRRRERIQ
GGEVGSPQFT REYWPFEYPC YGTSDFRPPA YEIQTGNGRT LSDARYIEHH IYDGKTALQG
LPHVYTEAGD KVQTLELTLY DAFADLTITL VYNVFEDYDA ITRHTRFYSK SQNLFLNSAL
SVSVDFKNMP DEMIQLSGTA LREKHLHRRK LDCGTTSVDS TRGISSHQQN PFLALVNENT
TEDYGDAYGI GLVYSGNFTA AVHCDMHRSA RVQMGINPFH FKWQLLAGES FTTPEAVLVY
ASHGLGEMSR RFHRLYRKRL CRGYYRDAVR PVLLNTWEAA YFNINHDTIL KYAEKAKDVG
VELLVVDDGW FGKRDDDTSS LGDWVINEKK FPGGFQVLAK DLNKLGLKLG IWVEPEMISP
NSELYRQHPD WCIHADGYVR TQWRNQLVLD FSRDDVTDAM IEAISRVLDS ADIYYVKWDC
NRRLTECGSD ALPADRQGEF YHRYVLNLYR FLETLTQRFP HILFENCASG GGRFDAGMMY
YFPQTWVSDN SDAFARLKIQ YGSSLCYPPI AITAHISDVP NEQLGRTTPL SFRQHVSQPF
NLGYEMDLAK MDEIQLEQTC ENIALYKQIR ELVLNGEFYR LKSPYEGNET AWMLIAPDCS
QATVWYYKAL AQGEEAYLNV KLKGLNPNVR YYCKQTAQFY EGDVLMRVGL PIPWENGDFF
SCMWQFKQVK E
//