ID A0A1H8E7Y1_9BACI Unreviewed; 460 AA.
AC A0A1H8E7Y1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Magnesium transporter MgtE {ECO:0000256|RuleBase:RU362011};
GN ORFNames=SAMN05192533_109193 {ECO:0000313|EMBL:SEN15510.1};
OS Mesobacillus persicus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Mesobacillus.
OX NCBI_TaxID=930146 {ECO:0000313|EMBL:SEN15510.1, ECO:0000313|Proteomes:UP000198553};
RN [1] {ECO:0000313|Proteomes:UP000198553}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B48,IBRC-M 10115,DSM 25386,CECT 8001
RC {ECO:0000313|Proteomes:UP000198553};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a magnesium transporter.
CC {ECO:0000256|RuleBase:RU362011}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU362011}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362011};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362011}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC41A transporter family.
CC {ECO:0000256|ARBA:ARBA00009749, ECO:0000256|RuleBase:RU362011}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362011}.
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DR EMBL; FOBW01000009; SEN15510.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H8E7Y1; -.
DR STRING; 930146.SAMN05192533_109193; -.
DR OrthoDB; 9790355at2; -.
DR Proteomes; UP000198553; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd04606; CBS_pair_Mg_transporter; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.25.60.10; MgtE N-terminal domain-like; 1.
DR Gene3D; 1.10.357.20; SLC41 divalent cation transporters, integral membrane domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR006668; Mg_transptr_MgtE_intracell_dom.
DR InterPro; IPR038076; MgtE_N_sf.
DR InterPro; IPR006669; MgtE_transporter.
DR InterPro; IPR006667; SLC41_membr_dom.
DR InterPro; IPR036739; SLC41_membr_dom_sf.
DR NCBIfam; TIGR00400; mgtE; 1.
DR PANTHER; PTHR43773; MAGNESIUM TRANSPORTER MGTE; 1.
DR PANTHER; PTHR43773:SF1; MAGNESIUM TRANSPORTER MGTE; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01769; MgtE; 1.
DR Pfam; PF03448; MgtE_N; 1.
DR SMART; SM00116; CBS; 2.
DR SMART; SM00924; MgtE_N; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF161093; MgtE membrane domain-like; 1.
DR SUPFAM; SSF158791; MgtE N-terminal domain-like; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Cell membrane {ECO:0000256|RuleBase:RU362011};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU362011};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362011};
KW Metal-binding {ECO:0000256|RuleBase:RU362011};
KW Reference proteome {ECO:0000313|Proteomes:UP000198553};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362011};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362011};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362011}.
FT TRANSMEM 293..310
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362011"
FT TRANSMEM 322..346
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362011"
FT TRANSMEM 367..388
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362011"
FT TRANSMEM 394..420
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362011"
FT DOMAIN 147..209
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 211..269
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 460 AA; 51346 MW; 54E5C4FB6217DD1D CRC64;
MSESSQESNQ KQHIDKELLM ESLKNDNIEN FRSEFLDLHA YDQASFFMEL NEEERLHVYH
FLSPEEMANL FENLEIEDDE YSDVLAEMSP NYAADMLSNM YADDAVDVLN ELDKDQVVSY
LTIMNKDSAQ EIKELLHYEE YTAGSIMTTE FIAIAANQTV RSAMHILKSK APSAETIYYV
YVVDEDRTLV GVLTLRDLIV NEDDVMISEI MYDRVVSVSV GEDQEEVARM MRDYDFLALP
VVDFQNHLLG IITVDDIIDV MEEEASDDYS KLAGIADLDS IDRNPISAAK KRLPWLVILL
FLGMFTASLI GRFEETLDKV AILAVFIPLI AGMAGNTGTQ ALAVAVRGIA TGDLEKEKIM
KIISREAGTG VITGTTCGIL VTFIVYFWQG DLFLGGLVGI SIFFALIVAT LAGSLVPLIM
HRLKIDPAVA SGPFITTIND IISILIYFGI ATAFMSYLTR
//
