ID A0A1H8EA25_9RHOB Unreviewed; 315 AA.
AC A0A1H8EA25;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Lactate dehydrogenase {ECO:0000313|EMBL:SEN15687.1};
GN ORFNames=SAMN05216227_100894 {ECO:0000313|EMBL:SEN15687.1};
OS Pseudorhodobacter antarcticus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Pseudorhodobacter.
OX NCBI_TaxID=1077947 {ECO:0000313|EMBL:SEN15687.1, ECO:0000313|Proteomes:UP000183002};
RN [1] {ECO:0000313|EMBL:SEN15687.1, ECO:0000313|Proteomes:UP000183002}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.10836 {ECO:0000313|EMBL:SEN15687.1,
RC ECO:0000313|Proteomes:UP000183002};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
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DR EMBL; FOCO01000008; SEN15687.1; -; Genomic_DNA.
DR RefSeq; WP_050520105.1; NZ_LGHU01000072.1.
DR AlphaFoldDB; A0A1H8EA25; -.
DR STRING; 1077947.SAMN05216227_100894; -.
DR OrthoDB; 9793626at2; -.
DR Proteomes; UP000183002; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd12156; HPPR; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996:SF178; 2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED; 1.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000183002}.
FT DOMAIN 45..315
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 109..283
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 315 AA; 33601 MW; 846B624A4B4249B3 CRC64;
MTLPTLLAVG TFNDWDVPDM RNGFDLVTIA SITDLAGLDA GLRGQVRAVA YKGHKPFDGA
QMDLLPALEI IANYGVGYDA IDVVAATARK VRVTNTPDVL NDDVADLAVG MLLSFTRNMA
ANSAWLARGD WAEKGDPPLA RKLSGTRVGI MGLGRIGREI ADRLAAFKME IHYHSRTAKD
TPAGWVWHAT PESLAASCDY MVVALVGGKA TEGYVSASVI AAMGADAVIA NISRGSTIDE
TALLDALENR RIRGAALDVF RVEPALDPRF LALSNVYLQP HQGSATIETR KGMGALQRAN
IRAHLSGQPL LTPVN
//
